Evaluating Zika Virus Pathogenesis in Immunocompromised Mice.
Animals
Disease Models, Animal
Female
Host-Pathogen Interactions
/ immunology
Humans
Immunocompromised Host
Male
Mice
Mice, 129 Strain
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Knockout
Receptor, Interferon alpha-beta
/ deficiency
Viral Plaque Assay
Virology
/ methods
Zika Virus
/ immunology
Zika Virus Infection
/ immunology
Animal model
Flavivirus
Interferon
Mouse
Pathogenesis
Zika virus
Journal
Methods in molecular biology (Clifton, N.J.)
ISSN: 1940-6029
Titre abrégé: Methods Mol Biol
Pays: United States
ID NLM: 9214969
Informations de publication
Date de publication:
2020
2020
Historique:
entrez:
6
5
2020
pubmed:
6
5
2020
medline:
11
3
2021
Statut:
ppublish
Résumé
Mouse models of Zika virus (ZIKV) infection, which recapitulate certain aspects of ZIKV infection in humans, have demonstrated their utility for studying ZIKV pathogenesis and for the initial screening of antivirals, experimental therapeutics, and candidate vaccines for protective efficacy against ZIKV infection. In this chapter we outline the available mouse models and describe the evaluation of ZIKV pathogenesis in an immunocompromised mouse model of ZIKV infection.
Identifiants
pubmed: 32367356
doi: 10.1007/978-1-0716-0581-3_3
doi:
Substances chimiques
Ifnar1 protein, mouse
0
Receptor, Interferon alpha-beta
156986-95-7
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM