Identification of a T
Journal
Journal of the European Academy of Dermatology and Venereology : JEADV
ISSN: 1468-3083
Titre abrégé: J Eur Acad Dermatol Venereol
Pays: England
ID NLM: 9216037
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
19
11
2019
revised:
25
03
2020
accepted:
03
04
2020
pubmed:
6
5
2020
medline:
15
5
2021
entrez:
6
5
2020
Statut:
ppublish
Résumé
Psoriasis is an immune-mediated, chronic inflammatory disease with diverse phenotypes. However, its biological diversity has not been well-characterized in Chinese psoriasis population. To characterize psoriasis biological heterogenicity using gene expression profiles of lesional skin biopsy specimens in a Chinese psoriasis population. Lesional tissues and blood samples from Chinese psoriasis patients (n = 40), atopic dermatitis (AD) patients (n = 25) and age-matched healthy controls (n = 19) were investigated by using real-time PCR array, histological evaluation and flow cytometry. Unsupervised hierarchical clustering was performed using gene expression profiles of patients with psoriasis. Two distinct psoriasis clusters were identified. Both clusters indicated high T Two distinct psoriasis clusters were identified. One presented early onset and a low eosinophil level, indicating T
Sections du résumé
BACKGROUND
BACKGROUND
Psoriasis is an immune-mediated, chronic inflammatory disease with diverse phenotypes. However, its biological diversity has not been well-characterized in Chinese psoriasis population.
OBJECTIVES
OBJECTIVE
To characterize psoriasis biological heterogenicity using gene expression profiles of lesional skin biopsy specimens in a Chinese psoriasis population.
METHODS
METHODS
Lesional tissues and blood samples from Chinese psoriasis patients (n = 40), atopic dermatitis (AD) patients (n = 25) and age-matched healthy controls (n = 19) were investigated by using real-time PCR array, histological evaluation and flow cytometry. Unsupervised hierarchical clustering was performed using gene expression profiles of patients with psoriasis.
RESULTS
RESULTS
Two distinct psoriasis clusters were identified. Both clusters indicated high T
CONCLUSIONS
CONCLUSIONS
Two distinct psoriasis clusters were identified. One presented early onset and a low eosinophil level, indicating T
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
150-158Subventions
Organisme : Shanghai Municipal Education Commission
ID : 17CG11
Organisme : Shanghai Municipal Education Commission
ID : 2018
Organisme : National Natural Science Foundation of China
ID : 81630083
Organisme : National Natural Science Foundation of China
ID : 81703150
Organisme : National Natural Science Foundation of China
ID : 81903190
Organisme : Shanghai Municipal Health Bureau
ID : 2017ZZ2026-02
Organisme : Science and Technology Commission of Shanghai Municipality
ID : 16YF1407400
Organisme : Science and Technology Commission of Shanghai Municipality
ID : 19YF1432400
Informations de copyright
© 2020 European Academy of Dermatology and Venereology.
Références
Fleming P, Bai JW, Pratt M et al. The prevalence of anxiety in patients with psoriasis: a systematic review of observational studies and clinical trials. J Eur Acad Dermatol Venereol 2017; 31: 798-807.
Hwang ST, Nijsten T, Elder JT. Recent highlights in psoriasis research. J Invest Dermatol 2017; 137: 550-556.
Liang Y, Sarkar MK, Tsoi LC et al. Psoriasis: a mixed autoimmune and autoinflammatory disease. Curr Opin Immunol 2017; 49: 1-8.
Michalek IM, Loring B, John SM. A systematic review of worldwide epidemiology of psoriasis. J Eur Acad Dermatol Venereol 2017; 31: 205-212.
Armstrong AW. Psoriasis. JAMA Dermatol 2017; 153: 956.
Karczewski J, Dobrowolska A, Rychlewska-Hanczewska A et al. New insights into the role of T cells in pathogenesis of psoriasis and psoriatic arthritis. Autoimmunity 2016; 49: 435-450.
Harden JL, Krueger JG, Bowcock AM. The immunogenetics of Psoriasis: a comprehensive review. J Autoimmun 2015; 64: 66-73.
Esaki H, Brunner PM, Renert-Yuval Y et al. Early-onset pediatric atopic dermatitis is TH2 but also TH17 polarized in skin. J Allergy Clin Immunol 2016; 138: 1639-1651.
Chan TC, Sanyal RD, Pavel AB et al. Atopic dermatitis in Chinese patients shows TH2/TH17 skewing with psoriasiform features. J Allergy Clin Immunol 2018; 142: 1013-1017.
Tahvili S, Zandieh B, Amirghofran Z. The effect of dimethyl fumarate on gene expression and the level of cytokines related to different T helper cell subsets in peripheral blood mononuclear cells of patients with psoriasis. Int J Dermatol 2015; 54: e254-e260.
Cordoro KM, Hitraya-Low M, Taravati K et al. Skin-infiltrating, interleukin-22-producing T cells differentiate pediatric psoriasis from adult psoriasis. J Am Acad Dermatol 2017; 77: 417-424.
Theodorakopoulou E, Yiu ZZ, Bundy C et al. Early- and late-onset psoriasis: a cross-sectional clinical and immunocytochemical investigation. Br J Dermatol 2016; 175: 1038-1044.
Yin X, Low HQ, Wang L et al. Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility. Nat Commun 2015; 6: 6916.
Swindell WR, Xing X, Stuart PE et al. Heterogeneity of inflammatory and cytokine networks in chronic plaque psoriasis. PLoS ONE 2012; 7: e34594.
Hanifin JM, Rajka G. Diagnostic features of atopic dermatitis. Acta Derm Venereol (Stockh) 1980; 92(suppl.): 44-47.
Noda S, Suarez-Farinas M, Ungar B et al. The Asian atopic dermatitis phenotype combines features of atopic dermatitis and psoriasis with increased TH17 polarization. J Allergy Clin Immunol 2015; 136: 1254-1264.
Quaranta M, Knapp B, Garzorz N et al. Intraindividual genome expression analysis reveals a specific molecular signature of psoriasis and eczema. Sci Transl Med 2014; 6: 244ra290.
Hahn M, Ghoreschi K. The role of IL-4 in psoriasis. Expert Rev Clin Immunol 2017; 13: 171-173.
Boehncke WH, Schon MP. Psoriasis. Lancet 2015; 386: 983-994.
Noda S, Krueger JG, Guttman-Yassky E. The translational revolution and use of biologics in patients with inflammatory skin diseases. J Allergy Clin Immunol 2015; 135: 324-336.
Baurecht H, Hotze M, Brand S et al. Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms. Am J Hum Genet 2015; 96: 104-120.
Choy DF, Hart KM, Borthwick LA et al. TH2 and TH17 inflammatory pathways are reciprocally regulated in asthma. Sci Transl Med 2015; 7: 301ra129.
Onderdijk AJ, Baerveldt EM, Kurek D et al. IL-4 downregulates IL-1beta and IL-6 and induces GATA3 in psoriatic epidermal cells: route of action of a Th2 cytokine. J Immunol 2015; 195: 1744-1752.
Nakajima S, Kitoh A, Egawa G et al. IL-17A as an inducer for Th2 immune responses in murine atopic dermatitis models. J Invest Dermatol 2014; 134: 2122-2130.
Lu Y, Kane S, Chen H et al. The role of 39 psoriasis risk variants on age of psoriasis onset. ISRN Dermatol 2013; 2013: 203941.
Nikamo P, Cheuk S, Lysell J et al. Genetic variants of the IL22 promoter associate to onset of psoriasis before puberty and increased IL-22 production in T cells. J Invest Dermatol 2014; 134: 1535-1541.
Chen L, Tsai TF. HLA-Cw6 and psoriasis. Br J Dermatol 2018; 178: 854-862.
Rosa G, Fernandez AP, Schneider S et al. Eosinophils are rare in biopsy specimens of psoriasis vulgaris. J Cutan Pathol 2017; 44: 1027-1032.
Penn L Brinster NK. Eosinophils among the histological features of psoriasis. Am J Dermatopathol 2019; 41: 347-349.
Kim HJ, Roh JY Jung Y. Eosinophils accelerate pathogenesis of psoriasis by supporting an inflammatory milieu that promotes neutrophil infiltration. J Invest Dermatol 2018; 138: 2185-2194.
Czarnowicki T, Esaki H, Gonzalez J et al. Early pediatric atopic dermatitis shows only a cutaneous lymphocyte antigen (CLA)(+) TH2/TH1 cell imbalance, whereas adults acquire CLA(+) TH22/TC22 cell subsets. J Allergy Clin Immunol 2015; 136: 941-951 e943.
Czarnowicki T, Gonzalez J, Shemer A et al. Severe atopic dermatitis is characterized by selective expansion of circulating TH2/TC2 and TH22/TC22, but not TH17/TC17, cells within the skin-homing T-cell population. J Allergy Clin Immunol 2015; 136: 104-115. e107.