Galanin Receptors as Drug Target for Novel Antidepressants: Review.
Galanin (GAL)
Galanin (GAL) receptors
depression
Journal
Biologics : targets & therapy
ISSN: 1177-5475
Titre abrégé: Biologics
Pays: New Zealand
ID NLM: 101321511
Informations de publication
Date de publication:
2020
2020
Historique:
received:
01
12
2019
accepted:
19
03
2020
entrez:
6
5
2020
pubmed:
6
5
2020
medline:
6
5
2020
Statut:
epublish
Résumé
Galanin (GAL) is a 29-amino-acid neuropeptide that serves multiple physiological functions throughout the central and peripheral nervous system. Its role involves in a range of physiological and pathological functions including control of food intake, neuro-protection, neuronal regeneration, energy expenditure, reproduction, water balance, mood, nociception and various neuroendocrine functions. The use of currently available antidepressant drugs raises concerns regarding efficacy and onset of action; therefore, the need for antidepressants with novel mechanisms is increasing. Presently, various studies revealed the link between GAL and depression. Attenuation of depressive symptoms is achieved through inhibition of GalR1 and GalR3 and activation of GalR2. However, lack of receptor selectivity of ligands has limited the complete elucidation of effects of different receptors in depression-like behavior. Studies have suggested that GAL enhances the action of selective serotonin reuptake inhibitors (SSRIs) and promotes availability of transcription proteins. This review addresses the role of GAL, GAL receptors (GALRs) ligands including selective peptides, and the mechanism of ligand receptor interaction in attenuating depressive symptoms.
Identifiants
pubmed: 32368008
doi: 10.2147/BTT.S240715
pii: 240715
pmc: PMC7183331
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
37-45Informations de copyright
© 2020 Demsie et al.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.
Références
Int J Neuropsychopharmacol. 2014 Oct 31;18(3):
pubmed: 25522404
Helminthologia. 2018 Jul 28;55(3):185-194
pubmed: 31662646
DNA Cell Biol. 1992 Jan-Feb;11(1):1-20
pubmed: 1310857
Horm Metab Res. 1999 May;31(5):330-4
pubmed: 10422730
J Neurochem. 1998 Dec;71(6):2252-9
pubmed: 9832122
Neuropsychopharmacology. 2002 Sep;27(3):341-56
pubmed: 12225692
J Cell Physiol. 2005 Feb;202(2):536-53
pubmed: 15316932
Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10470-5
pubmed: 15240875
Eur J Neurosci. 2006 Jul;24(2):499-508
pubmed: 16903855
Cell Mol Life Sci. 2008 Jun;65(12):1854-63
pubmed: 18500640
J Neural Transm (Vienna). 2007 Jan;114(1):115-25
pubmed: 16988794
Eur J Pharmacol. 2010 Jan 10;626(1):27-48
pubmed: 19837055
Eur J Pharmacol. 2010 Jan 10;626(1):9-17
pubmed: 19837050
Pharmacol Rev. 2015;67(1):118-75
pubmed: 25428932
Biochem Biophys Res Commun. 2018 Sep 3;503(1):79-85
pubmed: 29852172
Eur J Pharmacol. 1989 May 19;164(2):373-6
pubmed: 2474450
Acta Physiol Scand. 1988 Aug;133(4):579-81
pubmed: 2465672
Molecules. 2018 Jun 03;23(6):
pubmed: 29865267
EMBO J. 1989 Feb;8(2):413-20
pubmed: 2470586
Neuropharmacology. 2017 May 15;118:233-241
pubmed: 28288814
Cell Mol Neurobiol. 1995 Dec;15(6):653-73
pubmed: 8719035
J Biol Chem. 1997 Sep 26;272(39):24612-6
pubmed: 9305929
Results Probl Cell Differ. 1999;26:257-91
pubmed: 10453468
Mol Membr Biol. 2013 Mar;30(2):206-16
pubmed: 23237663
J Neurochem. 1998 Dec;71(6):2239-51
pubmed: 9832121
Hum Mol Genet. 2015 Jun 1;24(11):3082-91
pubmed: 25691535
Eur J Pharmacol. 1997 Jun 18;329(1):85-91
pubmed: 9218688
FEBS Lett. 1983 Nov 28;164(1):124-8
pubmed: 6197320
J Neurochem. 2013 Oct;127(1):114-23
pubmed: 23600864
Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):874-9
pubmed: 15647369
J Biol Chem. 1998 Sep 4;273(36):23321-6
pubmed: 9722565
Neurosci Lett. 2018 Aug 10;681:26-30
pubmed: 29787787
Trends Pharmacol Sci. 2000 Mar;21(3):109-17
pubmed: 10689365
Neuroscience. 1995 Feb;64(4):861-74
pubmed: 7538638
Brain Struct Funct. 2016 Dec;221(9):4491-4504
pubmed: 26792005
Ann N Y Acad Sci. 1996 Mar 22;780:193-212
pubmed: 8602734
Neuropharmacology. 2019 Sep 1;155:104-112
pubmed: 31128121
Biochem Biophys Res Commun. 2010 Mar 19;393(4):767-72
pubmed: 20171159
Front Cell Neurosci. 2018 May 01;12:119
pubmed: 29765307
Int J Neuropsychopharmacol. 2004 Jun;7(2):193-218
pubmed: 15003145
Behav Brain Res. 2016 Nov 1;314:125-33
pubmed: 27498247
J Comp Neurol. 1986 Jun 22;248(4):475-517
pubmed: 2424949
J Cereb Blood Flow Metab. 1989 Jun;9(3):271-9
pubmed: 2497110
Brain Struct Funct. 2016 Nov;221(8):4129-4139
pubmed: 26666529
Inflammopharmacology. 2012 Jun;20(3):127-50
pubmed: 22271002
Neuroscience. 1998 Aug;85(3):827-35
pubmed: 9639276
Neurosci Lett. 2001 Feb 16;299(1-2):145-9
pubmed: 11166958
Brain Res. 1991 Sep 27;560(1-2):251-9
pubmed: 1836971
FEBS Lett. 1997 Jul 14;411(2-3):225-30
pubmed: 9271210
Biochemistry. 2002 Jul 2;41(26):8298-309
pubmed: 12081478
Biochem Biophys Res Commun. 1993 Mar 31;191(3):1224-9
pubmed: 7682064
Life Sci. 1998;62(17-18):1647-52
pubmed: 9585151
Neuropharmacology. 2011 Jul-Aug;61(1-2):80-6
pubmed: 21396946
Brain Res Rev. 2008 Aug;58(2):415-52
pubmed: 18222544
Sci STKE. 2004 Mar 16;2004(225):re5
pubmed: 15039492
Am J Psychiatry. 2006 Jan;163(1):28-40
pubmed: 16390886
Brain Res Mol Brain Res. 1995 Dec 28;34(2):179-89
pubmed: 8750821
Brain Res. 2001 Nov 16;919(1):169-74
pubmed: 11689176
Curr Protein Pept Sci. 2014;15(7):666-72
pubmed: 25175455
Eur J Neurosci. 1998 Apr;10(4):1230-40
pubmed: 9749777
Pharmacol Ther. 2007 Aug;115(2):177-207
pubmed: 17604107
Mol Psychiatry. 2012 Apr;17(4):377-88
pubmed: 22230881
Trends Neurosci. 1989 Aug;12(8):278-82
pubmed: 2475942
ACS Omega. 2017 Aug 31;2(8):4779-4789
pubmed: 28920103
Biochemistry. 1998 May 12;37(19):6711-7
pubmed: 9578554
Neuropeptides. 2017 Aug;64:39-45
pubmed: 28196617
Neuroreport. 2000 Dec 18;11(18):3943-8
pubmed: 11192606
Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):E4726-35
pubmed: 27457954
Biochem Biophys Res Commun. 2014 Sep 26;452(3):347-53
pubmed: 25152404
Nature. 1996 Jul 4;382(6586):83-7
pubmed: 8657310
Synapse. 2014 May;68(5):179-93
pubmed: 24430888
Ann N Y Acad Sci. 1998 Dec 21;863:252-63
pubmed: 9928176
Neurosci Lett. 1995 Nov 17;200(2):121-4
pubmed: 8614559
Exp Suppl. 2010;102:113-31
pubmed: 21299065
Brain Res. 2010 Feb 16;1314:206-18
pubmed: 19699187
Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):9780-3
pubmed: 7524088
Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):E1666-73
pubmed: 24706871
J Chem Neuroanat. 2002 Nov;24(4):257-68
pubmed: 12406501
Neurosci Lett. 1987 Jul 22;78(2):127-31
pubmed: 2442671
Ann N Y Acad Sci. 1998 Dec 21;863:364-82
pubmed: 9928183
Pharmacol Ther. 2006 May;110(2):135-370
pubmed: 16522330