Inhaled Corticosteroids in COPD: Trying to Make a Long Story Short.
BERN
COPD
COPD exacerbations
inhaled corticosteroids
Journal
International journal of chronic obstructive pulmonary disease
ISSN: 1178-2005
Titre abrégé: Int J Chron Obstruct Pulmon Dis
Pays: New Zealand
ID NLM: 101273481
Informations de publication
Date de publication:
2020
2020
Historique:
received:
04
10
2019
accepted:
21
02
2020
entrez:
6
5
2020
pubmed:
6
5
2020
medline:
29
6
2021
Statut:
epublish
Résumé
The use of inhaled corticosteroids (ICSs) in long-term treatment of COPD has been a debated topic for a long time. According to the evidence produced till now, ICSs are presently advocated in combination with long-acting bronchodilators for high-risk symptomatic COPD patients with a history of frequent COPD exacerbations. However, the heterogeneity of COPD patients in terms of prevalent underlying disease, with its associated biological and functional characteristics, and different types of exacerbation makes this recommendation highly questionable. This review aims to discuss the usefulness of ICSs in the pharmacological management of COPD and trys to detect those aspects that may likely anticipate a beneficial response following their therapeutic use related to respiratory function, functional decline, prevention of exacerbation, and quality of life. In this respect, the BERN acronym, meaning Bronchiolitis, Eosinophilia, Responsiveness to bronchodilator, and Non-smoker, may be of practical utility to select among COPD patients those that can take more advantage from ICS adoption when positive and vice versa when negative.
Identifiants
pubmed: 32368028
doi: 10.2147/COPD.S233462
pii: 233462
pmc: PMC7182685
doi:
Substances chimiques
Adrenal Cortex Hormones
0
Bronchodilator Agents
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
821-829Informations de copyright
© 2020 Tantucci and Pini.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.
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