The Use of a New Food-Grade Lecithin Formulation of Highly Standardized Ginger (
Phytosome®
dietary supplements
knee osteoarthritis
pain
Journal
Journal of pain research
ISSN: 1178-7090
Titre abrégé: J Pain Res
Pays: New Zealand
ID NLM: 101540514
Informations de publication
Date de publication:
2020
2020
Historique:
received:
06
05
2019
accepted:
25
02
2020
entrez:
6
5
2020
pubmed:
6
5
2020
medline:
6
5
2020
Statut:
epublish
Résumé
To evaluate the efficacy of a new food-grade lecithin formulation of standardized extracts of Pilot study with one-group pretest-posttest quasi-experimental design in which 50 subjects with moderate knee osteoarthritis (OA) (mean age: 62.46±8.45) were supplied for four weeks with two tablets/day. Primary outcomes were 1) the evaluation of pain intensity, by a 30-day visual analogue scale (VAS) and 2) the assessment of knee function by WOMAC (Western Ontario and McMaster Universities Arthritis) Index and by Tegner Lysholm Knee Scoring collected at baseline, at 15 and 30 days after treatment. Secondary outcomes were 3) health-related quality of life, by the ShortForm36 (SF-36); 4) inflammation grade by C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR); and 5) body composition by dual-energy X-ray absorptiometry (DXA) measured at baseline and 30 days after treatment. Data showed significant effects of supplement intake for WOMAC (β=-3.27, p<0.0001), Lysholm (β=1.06, p=0.0003), CRP (β=-0.13, p=0.006), ESR (β=-3.09, p=0.004), physical activity (β=4.3, p=0.009) and fat-free mass (β=376.7, p=0.046). A significant VAS's decrease over time was observed in both knees (left: β=-0.08, p<0.0001; right: β=-0.07, p<0.0001). The tested formulation seems to be effective and also free of side effects.
Identifiants
pubmed: 32368129
doi: 10.2147/JPR.S214488
pii: 214488
pmc: PMC7183537
doi:
Types de publication
Journal Article
Langues
eng
Pagination
761-770Informations de copyright
© 2020 Rondanelli et al.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.
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