Design of the β3-Adrenergic Agonist Treatment in Chronic Pulmonary Hypertension Secondary to Heart Failure Trial.
CCT, cardiac computed tomography
CMR, cardiac magnetic resonance
CpcPH, combined pre- and post-capillary pulmonary hypertension
ECG, electrocardiography
HF, heart failure
ITT, intention to treat
IpcPH, isolated post-capillary pulmonary hypertension
LHD, left heart disease
LV, left ventricular
LVEF, left ventricular ejection fraction
NT-proBNP, N-terminal prohormone of brain natriuretic peptide
NYHA, New York Heart Association
PAP, pulmonary artery pressure
PH, pulmonary hypertension
PP, Per protocol
PVR, pulmonary vascular resistance
RV, right ventricle
adrenoreceptors
cGMP, cyclic guanosine monophosphate
imaging
pulmonary hypertension
treatment
β3AR, beta-3 adrenoreceptor
Journal
JACC. Basic to translational science
ISSN: 2452-302X
Titre abrégé: JACC Basic Transl Sci
Pays: United States
ID NLM: 101677259
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
27
09
2019
revised:
02
01
2020
accepted:
02
01
2020
entrez:
6
5
2020
pubmed:
6
5
2020
medline:
6
5
2020
Statut:
epublish
Résumé
Combined pre-and post-capillary hypertension (CpcPH) is a relatively common complication of heart failure (HF) associated with a poor prognosis. Currently, there is no specific therapy approved for this entity. Recently, treatment with beta-3 adrenergic receptor (β3AR) agonists was able to improve pulmonary hemodynamics and right ventricular (RV) performance in a translational, large animal model of chronic PH. The authors present the design of a phase II randomized clinical trial that tests the benefits of mirabegron (a clinically available β3AR agonist) in patients with CpcPH due to HF. The effect of β3AR treatment will be evaluated on pulmonary hemodynamics, as well as clinical, biochemical, and advanced cardiac imaging parameters. (Beta3 Agonist Treatment in Chronic Pulmonary Hypertension Secondary to Heart Failure [SPHERE-HF]; NCT02775539).
Identifiants
pubmed: 32368692
doi: 10.1016/j.jacbts.2020.01.009
pii: S2452-302X(20)30022-X
pmc: PMC7188870
doi:
Banques de données
ClinicalTrials.gov
['NCT02775539']
Types de publication
Journal Article
Langues
eng
Pagination
317-327Informations de copyright
© 2020 The Authors.
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