Black raspberries suppress pancreatic cancer through modulation of NKp46

KrasLSL.G12D/+-Trp53LSL.R172H/+-Pdx-1-Cre PDAC patients Pancreatic ductal adenocarcinoma black raspberries butyrate cancer immunity orthotopic xenograft

Journal

Food frontiers
ISSN: 2643-8429
Titre abrégé: Food Front
Pays: United States
ID NLM: 101762101

Informations de publication

Date de publication:
Mar 2020
Historique:
entrez: 6 5 2020
pubmed: 6 5 2020
medline: 6 5 2020
Statut: ppublish

Résumé

Pancreatic ductal adenocarcinoma (PDAC) is a fatal disease with a low survival rate (9%). Epidemiologic studies show that healthy dietary patterns enriched of fruits and vegetables lower the risk of PDAC. We previously showed that supplementing black raspberries (BRBs) to patients with colorectal cancer increased tumor-infiltrating NK cells and their cytotoxicity. We aimed to determine whether BRBs combat PDAC by modulating cancer immunity. NOD.SCID mice lacking T and B cells were injected with human Panc-1-Luc cells orthotopically, and immunocompetent

Identifiants

pubmed: 32368735
doi: 10.1002/fft2.1
pmc: PMC7197210
mid: NIHMS1551961
doi:

Types de publication

Journal Article

Langues

eng

Pagination

70-82

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI129582
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA185301
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS106170
Pays : United States
Organisme : NCI NIH HHS
ID : R21 CA223400
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA068458
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA033572
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA148818
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA247550
Pays : United States

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Auteurs

Pan Pan (P)

Division of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin.

Zheng Zhu (Z)

Department of Hematology & Hematopoietic Cell Transplantation, City of Hope National Medical Center and Beckman Research Institute.

Kiyoko Oshima (K)

Department of Pathology, Johns Hopkins University.

Mohammed Aldakkak (M)

Department of Surgery, Medical College of Wisconsin.

Susan Tsai (S)

Department of Surgery, Medical College of Wisconsin.

Yi-Wen Huang (YW)

Department of Obstetrics and Gynecology, Medical College of Wisconsin.

Wenjuan Dong (W)

Department of Hematology & Hematopoietic Cell Transplantation, City of Hope National Medical Center and Beckman Research Institute.

Jianying Zhang (J)

Division of Biostatistics, Department of Science of Informatics, City of Hope National Medical Center and Beckman Research Institute.

Chien-Wei Lin (CW)

Division of Biostatistics, Medical College of Wisconsin.

Youwei Wang (Y)

The James Cancer Hospital, The Ohio State University.

Martha Yearsley (M)

Department of Pathology, The Ohio State University.

Jianhua Yu (J)

Department of Hematology & Hematopoietic Cell Transplantation, City of Hope National Medical Center and Beckman Research Institute.

Li-Shu Wang (LS)

Division of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin.

Classifications MeSH