Direct Relationship Between Metabolic Flexibility Measured During Glucose Clamp and Prolonged Fast in Men.
Journal
Obesity (Silver Spring, Md.)
ISSN: 1930-739X
Titre abrégé: Obesity (Silver Spring)
Pays: United States
ID NLM: 101264860
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
11
12
2019
revised:
06
02
2020
accepted:
25
02
2020
pubmed:
6
5
2020
medline:
22
9
2020
entrez:
6
5
2020
Statut:
ppublish
Résumé
This study aimed to determine the relationship between metabolic flexibility (MetFlex) measured during a euglycemic-hyperinsulinemic clamp and a prolonged fast. This study also analyzed the association between MetFlex and metabolic health. Eighteen healthy men (mean [SD]: 22 [2] years old; BMI: 22 [1] kg/m MetFlex during the clamp related directly with MetFlex during prolonged fast (r = 0.59, P = 0.014). Using the median of MetFlex for each challenge, this study split participants into high or low MetFlex. Participants with high or low MetFlex to both challenges were identified. Participants with high MetFlex had 3% lower serum low-density lipoprotein cholesterol than participants with low MetFlex (P = 0.021). Measuring MetFlex during a clamp or a prolonged fast produces similar results, despite challenging the oxidation of different substrates. An impaired MetFlex in response to these challenges may be an early event in the development of abnormal lipid metabolism.
Substances chimiques
Insulin
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1110-1116Subventions
Organisme : Fondo Nacional de Desarrollo Científico y Tecnológico
ID : 11180361
Pays : International
Organisme : Fondo Nacional de Desarrollo Científico y Tecnológico
ID : 1170117
Pays : International
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2020 The Obesity Society.
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