Disease Severity Is Associated with Alexithymia in Patients with Atopic Dermatitis.

Adult Affective Symptoms / diagnosis Cross-Sectional Studies Dermatitis, Atopic / diagnosis Female Humans Male Middle Aged Severity of Illness Index
Alexithymia Atopic dermatitis Comorbidity Eczema Area and Severity Index

Journal

Dermatology (Basel, Switzerland)
ISSN: 1421-9832
Titre abrégé: Dermatology
Pays: Switzerland
ID NLM: 9203244

Informations de publication

Date de publication:
2020
Historique:
received: 30 01 2020
accepted: 08 03 2020
pubmed: 6 5 2020
medline: 27 4 2021
entrez: 6 5 2020
Statut: ppublish

Résumé

Atopic dermatitis (AD) is a chronic inflammatory skin disorder that is associated with higher rates of psychological disorders, but limited evidence supported the association with alexithymia, a psychoaffective dysfunction. This study was aimed to investigate the occurrence of alexithymia in AD patients, compared to healthy subjects. This cross-sectional study assessed AD severity by the Eczema Area and Severity Index (EASI) score, sleeplessness and itch by a numeric rating scale (NRS), and alexithymia by the 20-item Toronto Alexithymia Scale (TAS-20) score. The association between disease characteristics and alexithymia was evaluated through several logistic regression models. 202 AD patients and 240 healthy subjects were included in this study. The alexithymic personality trait (TAS-20 ≥51) was more frequently observed among AD patients compared to the control group (62.4% [126/202] vs. 29.2% [70/240], p < 0.0001). In particular, alexithymia (TAS-20 score ≥61) was detected in a significantly higher number of AD patients than in the controls (27.7% [56/202] vs. 7.5% [18/240]; p < 0.0001), whereas borderline alexithymia was detected in 34.6% (70/202) of AD patients compared to 21.7% of healthy controls. Alexithymia was more common among severe AD patients (43.6%) compared to mild AD patients (15.6%) and correlated with itch intensity and sleep disturbances. Among clinical variables, ordered logistic regression analyses revealed disease severity as predictor of alexithymia. Indeed, univariate analysis showed EASI score, sleep NRS, and itch NRS being significantly associated with alexithymia, while a multivariate model identified increased EASI score values as predicting factor. This study described alexithymia in AD patients correlating its occurrence with clinical AD severity markers (EASI score, itch, and sleeplessness) and identifying the increase in EASI score as predicting factor.

Sections du résumé

BACKGROUND BACKGROUND
Atopic dermatitis (AD) is a chronic inflammatory skin disorder that is associated with higher rates of psychological disorders, but limited evidence supported the association with alexithymia, a psychoaffective dysfunction.
OBJECTIVES OBJECTIVE
This study was aimed to investigate the occurrence of alexithymia in AD patients, compared to healthy subjects.
METHODS METHODS
This cross-sectional study assessed AD severity by the Eczema Area and Severity Index (EASI) score, sleeplessness and itch by a numeric rating scale (NRS), and alexithymia by the 20-item Toronto Alexithymia Scale (TAS-20) score. The association between disease characteristics and alexithymia was evaluated through several logistic regression models.
RESULTS RESULTS
202 AD patients and 240 healthy subjects were included in this study. The alexithymic personality trait (TAS-20 ≥51) was more frequently observed among AD patients compared to the control group (62.4% [126/202] vs. 29.2% [70/240], p < 0.0001). In particular, alexithymia (TAS-20 score ≥61) was detected in a significantly higher number of AD patients than in the controls (27.7% [56/202] vs. 7.5% [18/240]; p < 0.0001), whereas borderline alexithymia was detected in 34.6% (70/202) of AD patients compared to 21.7% of healthy controls. Alexithymia was more common among severe AD patients (43.6%) compared to mild AD patients (15.6%) and correlated with itch intensity and sleep disturbances. Among clinical variables, ordered logistic regression analyses revealed disease severity as predictor of alexithymia. Indeed, univariate analysis showed EASI score, sleep NRS, and itch NRS being significantly associated with alexithymia, while a multivariate model identified increased EASI score values as predicting factor.
CONCLUSION CONCLUSIONS
This study described alexithymia in AD patients correlating its occurrence with clinical AD severity markers (EASI score, itch, and sleeplessness) and identifying the increase in EASI score as predicting factor.

Identifiants

DOI: 10.1159/000507246 PMID: 32369808
pubmed: 32369808
pii: 000507246
doi: 10.1159/000507246
doi:

Types de publication

Journal Article Multicenter Study

Langues

eng

Sous-ensembles de citation

IM

Pagination

329-335

Informations de copyright

© 2020 S. Karger AG, Basel.

Auteurs

Andrea Chiricozzi (A)

Institute of Dermatology, Catholic University, Rome, Italy, chiricozziandrea@gmail.com.
Dermatology Unit, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy, chiricozziandrea@gmail.com.

Maria Esposito (M)

Dermatology Unit, Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.

Paolo Gisondi (P)

Section of Dermatology and Venereology, Department of Medicine, University of Verona, Verona, Italy.

Mario Valenti (M)

Dermatology, Humanitas Clinical and Research Center, Department of Biomedical Sciences, Humanitas University, IRCCS, Milan, Italy.

Niccolò Gori (N)

Institute of Dermatology, Catholic University, Rome, Italy.

Giulia Giovanardi (G)

Institute of Dermatology, Catholic University, Rome, Italy.

Francesco Bellinato (F)

Section of Dermatology and Venereology, Department of Medicine, University of Verona, Verona, Italy.

Clara De Simone (C)

Institute of Dermatology, Catholic University, Rome, Italy.
Dermatology Unit, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy.

Antonio Costanzo (A)

Dermatology, Humanitas Clinical and Research Center, Department of Biomedical Sciences, Humanitas University, IRCCS, Milan, Italy.

Maria Concetta Fargnoli (MC)

Dermatology Unit, Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.

Ketty Peris (K)

Institute of Dermatology, Catholic University, Rome, Italy.
Dermatology Unit, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Disease Severity Is Associated with...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Comportement › Symptômes comportementaux › Symptômes affectifs › Disease Severity Is Associated with...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études transversales › Disease Severity Is Associated with...
questionsmedicales.fr › Maladies du système immunitaire › Hypersensibilité › Hypersensibilité immédiate › Eczéma atopique › Disease Severity Is Associated with...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Disease Severity Is Associated with...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Disease Severity Is Associated with...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Enquêtes et questionnaires › Enquêtes de santé › Indicateurs d'état de santé › Acuité des besoins du patient › Indice de gravité de la maladie › Disease Severity Is Associated with...