Preparation of Terpenoid-Invasomes with Selective Activity against
E. coli
S. aureus
bactericidal
camphor
cineol
invasomes
menthol
terpenoids
thymol
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
01 May 2020
01 May 2020
Historique:
received:
07
04
2020
revised:
28
04
2020
accepted:
30
04
2020
entrez:
7
5
2020
pubmed:
7
5
2020
medline:
7
5
2020
Statut:
epublish
Résumé
Terpenoids are natural plant-derived products that are applied to treat a broad range of human diseases, such as airway infections and inflammation. However, pharmaceutical applications of terpenoids against bacterial infection remain challenging due to their poor water solubility. Here, we produce invasomes encapsulating thymol, menthol, camphor and 1,8-cineol, characterize them via cryo transmission electron microscopy and assess their bactericidal properties. While control- and cineol-invasomes are similarly distributed between unilamellar and bilamellar vesicles, a shift towards unilamellar invasomes is observable after encapsulation of thymol, menthol or camphor. Thymol- and camphor-invasomes show a size reduction, whereas menthol-invasomes are enlarged and cineol-invasomes remain unchanged compared to control. While thymol-invasomes lead to the strongest growth inhibition of
Identifiants
pubmed: 32369920
pii: biomedicines8050105
doi: 10.3390/biomedicines8050105
pmc: PMC7277086
pii:
doi:
Types de publication
Journal Article
Langues
eng
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