Post-Translational Modifications of Transcription Factors Harnessing the Etiology and Pathophysiology in Colonic Diseases.
O-GlcNAcylation
SUMOylation
acetylation
methylation
phosphorylation
transcription factor
ubiquitination
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
01 May 2020
01 May 2020
Historique:
received:
31
03
2020
revised:
23
04
2020
accepted:
30
04
2020
entrez:
7
5
2020
pubmed:
7
5
2020
medline:
7
2
2021
Statut:
epublish
Résumé
Defects in mucosal immune balance can lead to colonic diseases such as inflammatory bowel diseases and colorectal cancer. With the advancement of understanding for the immunological and molecular basis of colonic disease, therapies targeting transcription factors have become a potential approach for the treatment of colonic disease. To date, the biomedical significance of unique post-translational modifications on transcription factors has been identified, including phosphorylation, methylation, acetylation, ubiquitination, SUMOylation, and O-GlcNAcylation. This review focuses on our current understanding and the emerging evidence of how post-translational regulations modify transcription factors involved in the etiology and pathophysiology of colonic disease as well as the implications of these findings for new therapeutic approaches in these disorders.
Identifiants
pubmed: 32369982
pii: ijms21093207
doi: 10.3390/ijms21093207
pmc: PMC7246881
pii:
doi:
Substances chimiques
Transcription Factors
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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