Monogalactosyldiacylglycerol and Sulfolipid Synthesis in Microalgae.
UDP-sulfoquinovose synthase
microalgae
monogalactosyldiacylglycerol synthase
monogalactosyldiacylglycerols
sulfoquinovosyldiacylglycerols
sulfoquinovosyltransferase
transcriptome analysis
Journal
Marine drugs
ISSN: 1660-3397
Titre abrégé: Mar Drugs
Pays: Switzerland
ID NLM: 101213729
Informations de publication
Date de publication:
01 May 2020
01 May 2020
Historique:
received:
12
04
2020
revised:
23
04
2020
accepted:
27
04
2020
entrez:
7
5
2020
pubmed:
7
5
2020
medline:
9
2
2021
Statut:
epublish
Résumé
Microalgae, due to their huge taxonomic and metabolic diversity, have been shown to be a valuable and eco-friendly source of bioactive natural products. The increasing number of genomic and transcriptomic data will give a great boost for the study of metabolic pathways involved in the synthesis of bioactive compounds. In this study, we analyzed the presence of the enzymes involved in the synthesis of monogalactosyldiacylglycerols (MGDGs) and sulfoquinovosyldiacylglycerols (SQDG). Both compounds have important biological properties. MGDGs present both anti-inflammatory and anti-cancer activities while SQDGs present immunostimulatory activities and inhibit the enzyme glutaminyl cyclase, which is involved in Alzheimer's disease. The Ocean Global Atlas (OGA) database and the Marine Microbial Eukaryotic Transcriptome Sequencing Project (MMETSP) were used to search MGDG synthase (MGD), UDP-sulfoquinovose synthase (SQD1), and sulfoquinovosyltransferase (SQD2) sequences along microalgal taxa.
Identifiants
pubmed: 32370033
pii: md18050237
doi: 10.3390/md18050237
pmc: PMC7281551
pii:
doi:
Substances chimiques
Galactolipids
0
Lipids
0
monogalactosyldiacylglycerol
0
sulfolipids
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Progetto POR Campania
ID : PG/2018/0494374
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