Synthetic Biology Approaches to Engineer
Saccharomyces cerevisiae
heterologous production
metabolic engineering
polyphenols biosynthesis
synthetic biology
Journal
Life (Basel, Switzerland)
ISSN: 2075-1729
Titre abrégé: Life (Basel)
Pays: Switzerland
ID NLM: 101580444
Informations de publication
Date de publication:
02 May 2020
02 May 2020
Historique:
received:
01
04
2020
revised:
22
04
2020
accepted:
30
04
2020
entrez:
7
5
2020
pubmed:
7
5
2020
medline:
7
5
2020
Statut:
epublish
Résumé
Polyphenols are plant secondary metabolites with diverse biological and potential therapeutic activities such as antioxidant, anti-inflammatory and anticancer, among others. However, their extraction from the native plants is not enough to satisfy the increasing demand for this type of compounds. The development of microbial cell factories to effectively produce polyphenols may represent the most attractive solution to overcome this limitation and produce high amounts of these bioactive molecules. With the advances in the synthetic biology field, the development of efficient microbial cell factories has become easier, largely due to the development of the molecular biology techniques and by the identification of novel isoenzymes in plants or simpler organisms to construct the heterologous pathways. Furthermore, efforts have been made to make the process more profitable through improvements in the host chassis. In this review, advances in the production of polyphenols by genetically engineered
Identifiants
pubmed: 32370107
pii: life10050056
doi: 10.3390/life10050056
pmc: PMC7281501
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Fundação para a Ciência e a Tecnologia
ID : SFRH/BD/138325/2018
Organisme : Fundação para a Ciência e a Tecnologia
ID : UIDB/BIO/04469/2020
Organisme : Fundação para a Ciência e a Tecnologia
ID : NORTE-01-0145-FEDER-000004
Organisme : European Regional Development Fund
ID : LISBOA-010145-FEDER-022059
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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