BAMBI and CHGA in Prion Diseases: Neuropathological Assessment and Potential Role as Disease Biomarkers.
Creutzfeldt-Jakob disease
biomarkers
bone morphogenetic protein and activin membrane-bound inhibitor
chromogranin A
neuroinflammation
prion disease
scrapie
sheep
transgenic mice
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
02 05 2020
02 05 2020
Historique:
received:
25
03
2020
revised:
25
04
2020
accepted:
29
04
2020
entrez:
7
5
2020
pubmed:
7
5
2020
medline:
7
4
2021
Statut:
epublish
Résumé
Prion diseases affect both animals and humans. Research in the natural animal model of the disease could help in the understanding of neuropathological mechanisms and in the development of biomarkers for human pathologies. For this purpose, we studied the expression of 10 genes involved in prion propagation in vitro in the central nervous system of scrapie-infected sheep. Dysregulated genes (
Identifiants
pubmed: 32370154
pii: biom10050706
doi: 10.3390/biom10050706
pmc: PMC7277700
pii:
doi:
Substances chimiques
Bambi protein, mouse
0
Biomarkers
0
Chromogranin A
0
Membrane Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Gobierno de Aragón
ID : C012/2014 and C020/2014 and Order IIU/2023/2017
Pays : International
Organisme : European Social Fund
ID : C012/2014 and C020/2014 and Order IIU/2023/2017
Pays : International
Organisme : Ministerio de Economía, Industria y Competitividad, Gobierno de España
ID : AGL2015-67945-P
Pays : International
Organisme : Ministerio de Ciencia e Innovación
ID : RTI2018-098711-B-I00
Pays : International
Organisme : European Regional Development Fund
ID : AGL2015-67945-P, RTI2018-098711-B-I00
Pays : International
Organisme : Gobierno de Aragón
ID : Grupo de Referencia LAGENBIO (A19-17R)
Pays : International
Organisme : European Social Fund
ID : Construyendo Europa desde Aragón: Grupo de Referencia LAGENBIO (A19-17R)
Pays : International
Organisme : Instituto de Salud Carlos III
ID : PI19/00144
Pays : International
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.
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