Novel Applications of Mesenchymal Stem Cell-derived Exosomes for Myocardial Infarction Therapeutics.
cardiac regeneration
cardioprotection
cardiovascular disease
cell-free therapy
exosomes
extracellular vesicles
mesenchymal stem cells
myocardial infarction
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
02 05 2020
02 05 2020
Historique:
received:
01
04
2020
revised:
22
04
2020
accepted:
27
04
2020
entrez:
7
5
2020
pubmed:
7
5
2020
medline:
7
4
2021
Statut:
epublish
Résumé
Cardiovascular diseases (CVDs) are the leading cause of mortality and morbidity globally, representing approximately a third of all deaths every year. The greater part of these cases is represented by myocardial infarction (MI), or heart attack as it is better known, which occurs when declining blood flow to the heart causes injury to cardiac tissue. Mesenchymal stem cells (MSCs) are multipotent stem cells that represent a promising vector for cell therapies that aim to treat MI due to their potent regenerative effects. However, it remains unclear the extent to which MSC-based therapies are able to induce regeneration in the heart and even less clear the degree to which clinical outcomes could be improved. Exosomes, which are small extracellular vesicles (EVs) known to have implications in intracellular communication, derived from MSCs (MSC-Exos), have recently emerged as a novel cell-free vector that is capable of conferring cardio-protection and regeneration in target cardiac cells. In this review, we assess the current state of research of MSC-Exos in the context of MI. In particular, we place emphasis on the mechanisms of action by which MSC-Exos accomplish their therapeutic effects, along with commentary on the current difficulties faced with exosome research and the ongoing clinical applications of stem-cell derived exosomes in different medical contexts.
Identifiants
pubmed: 32370160
pii: biom10050707
doi: 10.3390/biom10050707
pmc: PMC7277090
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : British Heart Foundation
ID : CH/15/1/31199
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RG/15/5/31446
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RG/20/9/35101
Pays : United Kingdom
Organisme : British Heart Foundation
ID : BHF-CVR2
Pays : United Kingdom
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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