Use of viruses for interrogating viscera-specific projections in central nervous system.
Brain circuit
Central nervous system
Organ function
Virus tract tracing
Viscera
Journal
Journal of neuroscience methods
ISSN: 1872-678X
Titre abrégé: J Neurosci Methods
Pays: Netherlands
ID NLM: 7905558
Informations de publication
Date de publication:
15 07 2020
15 07 2020
Historique:
received:
26
02
2020
revised:
28
04
2020
accepted:
28
04
2020
pubmed:
7
5
2020
medline:
22
6
2021
entrez:
7
5
2020
Statut:
ppublish
Résumé
Each internal organ may perform many different functions under central regulation, yet how these processes are coordinated is poorly understood. The last three decades have witnessed a renaissance in tract tracing with genetically engineered strains of viruses that rapidly interrogate viscera-specific projections in the CNS. The application of novel methods to study cell type-specific projections through trans-synaptically transmitted virus 'label' highlights projections exclusively originating from neurons expressing a very specific molecular phenotype. This has opened the door to neuroanatomical studies interrogating organ-specific projections in the CNS at an unprecedented scale. In this contribution to the Special Issue we present an overview of the present state and of future opportunities in charting viscera-brain specific connectivity and in linking brain circuits to internal organ function.
Identifiants
pubmed: 32371062
pii: S0165-0270(20)30180-1
doi: 10.1016/j.jneumeth.2020.108757
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
108757Informations de copyright
Copyright © 2020. Published by Elsevier B.V.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no competing interests. All authors confirm its accuracy.