Mesenchymal stem cell (MSc) secretome: A possible therapeutic strategy for intensive-care COVID-19 patients.
Animals
Betacoronavirus
Brazil
COVID-19
Coronavirus Infections
/ therapy
Critical Care
Culture Media, Conditioned
Exosomes
/ metabolism
Extracellular Vesicles
/ metabolism
Humans
Intensive Care Units
Mesenchymal Stem Cell Transplantation
Mesenchymal Stem Cells
/ metabolism
Metabolome
Mice
Pandemics
Plasma
/ immunology
Pneumonia, Viral
/ therapy
SARS-CoV-2
COVID-19
MSc secretome
Novel strategy
Journal
Medical hypotheses
ISSN: 1532-2777
Titre abrégé: Med Hypotheses
Pays: United States
ID NLM: 7505668
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
27
03
2020
accepted:
21
04
2020
pubmed:
7
5
2020
medline:
1
9
2020
entrez:
7
5
2020
Statut:
ppublish
Résumé
As an emerging global health challenge, COVID-19 requires international knowledge to reach novel possible therapeutic strategies, especially for intensive-care patients. During the early stages of infection, pneumocytes II are the primary infected cells, harming the respiratory system. We have previous evidence in murine models that MSc's secretome can be used to treat pulmonary injuries induced with bleomycin, due to its content: growth factors, extracellular vesicles, and exosomes. We hypothesize and strongly recommend MSc secretome testing and production, in xenofree conditions, to be used as an alternative approach in SARS-Cov-2 patients in critical conditions.
Identifiants
pubmed: 32371362
pii: S0306-9877(20)30552-1
doi: 10.1016/j.mehy.2020.109769
pmc: PMC7252028
pii:
doi:
Substances chimiques
Culture Media, Conditioned
0
Types de publication
Letter
Langues
eng
Sous-ensembles de citation
IM
Pagination
109769Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Références
Nature. 2020 Mar;579(7798):270-273
pubmed: 32015507
Lancet. 2020 Mar 28;395(10229):1054-1062
pubmed: 32171076
Trends Microbiol. 2020 Apr;28(4):239-240
pubmed: 32155431
J Clin Med. 2020 Mar 03;9(3):
pubmed: 32138309
J Cardiothorac Vasc Anesth. 2019 Apr;33(4):985-992
pubmed: 30206011
Histol Histopathol. 2020 Mar;35(3):289-301
pubmed: 31318036
JAMA Intern Med. 2020 Jul 1;180(7):934-943
pubmed: 32167524
Int J Surg. 2020 Apr;76:71-76
pubmed: 32112977
Front Cell Dev Biol. 2020 Feb 21;8:107
pubmed: 32154253
Pediatr Ann. 2020 Mar 1;49(3):e99-e100
pubmed: 32155273
Cell. 2020 Apr 16;181(2):271-280.e8
pubmed: 32142651