Formulation of Sugar/Hydrogel Inks for Rapid Thermal Response 4D Architectures with Sugar-derived Macropores.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
05 05 2020
05 05 2020
Historique:
received:
28
05
2019
accepted:
14
04
2020
entrez:
7
5
2020
pubmed:
7
5
2020
medline:
7
5
2020
Statut:
epublish
Résumé
Programmed, reshaping hydrogel architectures were fabricated from sugar/hydrogel inks via a three-dimensional printing method involving a stimuli-responsive polymer. We developed a new hydrogel ink composed of monomers (acrylamide [AAm]) and N-isopropylacrylamide [NIPAAm]), and sugar (mixture of glucose and sucrose) as a pore-generator, enabling to improve printability by increasing the ink's viscoelastic properties and induce the formation of macropores in the hydrogel architectures. This study demonstrated that creating macropores in such architectures enables rapid responses to stimuli that can facilitate four-dimensional printing. We printed bilayer structures from monomer inks to which we had added sugar, and we exposed them to processes that cross-linked the monomers and leached out the sugar to create macropores. In comparison with a conventional poly(N-isopropylacrylamide) hydrogel, the macroporous hydrogels prepared using polymerization in the presence of a high concentration of sugar showed higher swelling ratios and exhibited much faster response rates to temperature changes. We used rheometry and scanning electron microscopy to characterize the properties of these inks and hydrogels. The results suggest that this method may provide a readily available route to the rapid design and fabrication of shape-morphing hydrogel architectures with potential application in soft robotics, hydrogel actuators, and tissue engineering.
Identifiants
pubmed: 32371928
doi: 10.1038/s41598-020-64457-8
pii: 10.1038/s41598-020-64457-8
pmc: PMC7200689
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
7527Références
Kang, H.-W. et al. A 3D bioprinting system to produce human-scale tissue constructs with structural integrity. Nature Biotechnology 34, 312–319, https://doi.org/10.1038/nbt.3413 (2016).
doi: 10.1038/nbt.3413
pubmed: 26878319
Tamayol, A. et al. Bioactive Fibers: Hydrogel Templates for Rapid Manufacturing of Bioactive Fibers and 3D Constructs (Adv. Healthcare Mater. 14/2015). Advanced Healthcare Materials 4, 2050–2050, https://doi.org/10.1002/adhm.201570082 (2015).
doi: 10.1002/adhm.201570082
pubmed: 29896903
Truby, R. L. & Lewis, J. A. Printing soft matter in three dimensions. Nature 540, 371–378, https://doi.org/10.1038/nature21003 (2016).
doi: 10.1038/nature21003
pubmed: 27974748
Roh, S., Parekh, D. P., Bharti, B., Stoyanov, S. D. & Velev, O. D. 3D Printing by Multiphase Silicone/Water Capillary Inks. Advanced Materials 29, 1701554, https://doi.org/10.1002/adma.201701554 (2017).
doi: 10.1002/adma.201701554
Valentine, A. D. et al. Hybrid 3D Printing of Soft Electronics. Advanced Materials 29, 1703817, https://doi.org/10.1002/adma.201703817 (2017).
doi: 10.1002/adma.201703817
Farahani, R. D., Dubé, M. & Therriault, D. Three-Dimensional Printing of Multifunctional Nanocomposites: Manufacturing Techniques and Applications. Advanced Materials 28, 5794–5821, https://doi.org/10.1002/adma.201506215 (2016).
doi: 10.1002/adma.201506215
pubmed: 27135923
Cao, T. et al. Chelator-Free Conjugation of 99mTc and Gd3 to PEGylated Nanographene Oxide for Dual-Modality SPECT/MR Imaging of Lymph Nodes. ACS Applied Materials & Interfaces 9, 42612–42621, https://doi.org/10.1021/acsami.7b14836 (2017).
doi: 10.1021/acsami.7b14836
Palleau, E., Morales, D., Dickey, M. D. & Velev, O. D. Reversible patterning and actuation of hydrogels by electrically assisted ionoprinting. Nature Communications 4, https://doi.org/10.1038/ncomms3257 (2013).
Ionov, L. Polymeric Actuators. Langmuir 31, 5015–5024, https://doi.org/10.1021/la503407z (2015).
doi: 10.1021/la503407z
pubmed: 25386998
Deng, J. et al. Tunable Photothermal Actuators Based on a Pre-programmed Aligned Nanostructure. Journal of the American Chemical Society 138, 225–230, https://doi.org/10.1021/jacs.5b10131 (2016).
doi: 10.1021/jacs.5b10131
pubmed: 26678012
Hines, L., Petersen, K., Lum, G. Z. & Sitti, M. Soft Actuators for Small-Scale Robotics. Advanced Materials 29, 1603483, https://doi.org/10.1002/adma.201603483 (2017).
doi: 10.1002/adma.201603483
Gladman, A. S. et al. Biomimetic 4D printing. Nature Materials 15, 413–418, https://doi.org/10.1038/nmat4544 (2016).
doi: 10.1038/nmat4544
pubmed: 26808461
Raviv, D. et al. Active Printed Materials for Complex Self-Evolving Deformations. Scientific Reports 4, https://doi.org/10.1038/srep07422 (2015).
Ge, Q. et al. Multimaterial 4D Printing with Tailorable Shape Memory Polymers. Scientific Reports 6, https://doi.org/10.1038/srep31110 (2016).
Li, Y.-C., Zhang, Y. S., Akpek, A., Shin, S. R. & Khademhosseini, A. 4D bioprinting: the next-generation technology for biofabrication enabled by stimuli-responsive materials. Biofabrication 9, 012001, https://doi.org/10.1088/1758-5090/9/1/012001 (2016).
doi: 10.1088/1758-5090/9/1/012001
pubmed: 27910820
Forterre, Y., Skotheim, J. M., Dumais, J. & Mahadevan, L. How the Venus flytrap snaps. Nature 433, 421–425, https://doi.org/10.1038/nature03185 (2005).
doi: 10.1038/nature03185
pubmed: 15674293
Peng, X. & Wang, H. Shape Changing Hydrogels and Their Applications as Soft Actuators. J. Polym. Sci. Pol. Phys 56, 1314–1324, https://doi.org/10.1002/polb.24724 (2018).
doi: 10.1002/polb.24724
Pei, E. & Loh, G. H. Technological considerations for 4D printing: an overview. Prog. Addit. Manuf 3, 95–107, https://doi.org/10.1007/s40964-018-0047-1 (2018).
doi: 10.1007/s40964-018-0047-1
Jia, H. et al. Universal Soft Robotic Microgripper. Small 15, 1803870, https://doi.org/10.1002/smll.201803870 (2019).
doi: 10.1002/smll.201803870
Wang, E., Desai, M. S. & Lee, S.-W. Light-Controlled Graphene-Elastin Composite Hydrogel Actuators. Nano. Lett. 13, 2826–2830, https://doi.org/10.1021/nl401088b (2013).
doi: 10.1021/nl401088b
pubmed: 23647361
pmcid: 3737518
Mou, C.-L. et al. Monodisperse and Fast-Responsive Poly(N-isopropylacrylamide) Microgels with Open-Celled Porous Structure. Langmuir 30, 1455–1464, https://doi.org/10.1021/la4046379 (2014).
doi: 10.1021/la4046379
pubmed: 24437526
Zhang, J.-T., Cheng, S.-X., Huang, S.-W. & Zhuo, R.-X. Temperature-Sensitive Poly(N-isopropylacrylamide) Hydrogels with Macroporous Structure and Fast Response Rate. Macromolecular Rapid Communications 24, 447–451, https://doi.org/10.1002/marc.200390061 (2003).
doi: 10.1002/marc.200390061
Zhang, J.-T., Cheng, S.-X. & Zhuo, R.-X. Preparation of macroporous poly(N-isopropylacrylamide) hydrogel with improved temperature sensitivity. Journal of Polymer Science Part A: Polymer Chemistry 41, 2390–2392, https://doi.org/10.1002/pola.10785 (2003).
doi: 10.1002/pola.10785
Maeda, S., Kato, T., Kogure, H. & Hosoya, N. Rapid response of thermo-sensitive hydrogels with porous structures. Applied Physics Letters 106, 171909, https://doi.org/10.1063/1.4919585 (2015).
doi: 10.1063/1.4919585
Zhang, X.-Z. & Chu, C.-C. Thermosensitive PNIPAAm cryogel with superfast and stable oscillatory properties. Chemical Communications 1446–1447, https://doi.org/10.1039/b301423a (2003).
Chatterjee, P., Dai, A., Yu, H., Jiang, H. & Dai, L. L. Thermal and mechanical properties of poly(N-isopropylacrylamide)-based hydrogels as a function of porosity and medium change. Journal of Applied Polymer Science 132, 42776, https://doi.org/10.1002/app.42776 (2015).
doi: 10.1002/app.42776
Park, J. H. et al. Microporous cell-laden hydrogels for engineered tissue constructs. Biotechnology and Bioengineering 106, 138, https://doi.org/10.1002/bit.22667 (2010).
doi: 10.1002/bit.22667
pubmed: 20091766
pmcid: 2847036
Hong, S. et al. 3D Printing: 3D Printing of Highly Stretchable and Tough Hydrogels into Complex, Cellularized Structures. Advanced Materials 27, 4034–4034, https://doi.org/10.1002/adma.201501099 (2015).
doi: 10.1002/adma.201501099
pubmed: 26172844
Haq, M. A., Su, Y. & Wang., D. Mechanical properties of PNIPAM based hydrogels: A review. Materials Science and Engineering C 70, 842–855, https://doi.org/10.1016/j.msec.2016.09.081 (2017).
doi: 10.1016/j.msec.2016.09.081
pubmed: 27770962
Drury, J. L., Dennis, R. G. & Mooney, D. J. The tensile properties of alginate hydrogels. Biomaterials 25, 3187–3199, https://doi.org/10.1016/j.biomaterials.2003.10.002 (2004).
doi: 10.1016/j.biomaterials.2003.10.002
pubmed: 14980414
Wang, M. X. et al. Tough Photoluminescent Hydrogels Doped with Lanthanide. Macromolecular Rapid Communications 36, 465–471, https://doi.org/10.1002/marc.201400630 (2015).
doi: 10.1002/marc.201400630
pubmed: 25605548
Sun, J.-Y. et al. Highly stretchable and tough hydrogels. Nature 489, 133–136, https://doi.org/10.1038/nature11409 (2012).
doi: 10.1038/nature11409
pubmed: 22955625
pmcid: 3642868
Malda, J. et al. 25th Anniversary Article: Engineering Hydrogels for Biofabrication. Advanced Materials 25, 5011–5028, https://doi.org/10.1002/adma.201302042 (2013).
doi: 10.1002/adma.201302042
pubmed: 24038336
Smith, P. T., Basu, A., Saha, A. & Nelson, A. Chemical modification and printability of shear-thinning hydrogel inks for direct-write 3D printing. Polymer 152, 42–50, https://doi.org/10.1016/j.polymer.2018.01.070 (2018).
doi: 10.1016/j.polymer.2018.01.070
Ribeiro, A. C. F et al. Diffusion coefficient and electrical conductivities for calcium chloride aqueous solutions at 298.15 K and 310.15 K, Electrochimica Acta 54, 192–196,
Linder, P. W. et al. The diffusion coefficient of sucrose in water. A physical chemistry experiment. Journal of Chemical Education 53, 330–332, https://doi.org/10.1021/ed053p330 (1976), 10.1016/j.electacta.2008.08.011 (2008).
Caliari, S. R. & Burdick, J. A. A practical guide to hydrogels for cell culture. Nature Methods 13, 405–414, https://doi.org/10.1038/nmeth.3839 (2016).
doi: 10.1038/nmeth.3839
pubmed: 27123816
pmcid: 5800304
Otake, K., Inomata, H., Konno, M. & Saito, S. Thermal analysis of the volume phase transition with N-isopropylacrylamide gels. Macromolecules 23, 283–289, https://doi.org/10.1021/ma00203a049 (1990).
doi: 10.1021/ma00203a049