Combining native and 'omics' mass spectrometry to identify endogenous ligands bound to membrane proteins.


Journal

Nature methods
ISSN: 1548-7105
Titre abrégé: Nat Methods
Pays: United States
ID NLM: 101215604

Informations de publication

Date de publication:
05 2020
Historique:
received: 27 09 2019
accepted: 25 03 2020
entrez: 7 5 2020
pubmed: 7 5 2020
medline: 19 8 2020
Statut: ppublish

Résumé

Ligands bound to protein assemblies provide critical information for function, yet are often difficult to capture and define. Here we develop a top-down method, 'nativeomics', unifying 'omics' (lipidomics, proteomics, metabolomics) analysis with native mass spectrometry to identify ligands bound to membrane protein assemblies. By maintaining the link between proteins and ligands, we define the lipidome/metabolome in contact with membrane porins and a mitochondrial translocator to discover potential regulators of protein function.

Identifiants

pubmed: 32371966
doi: 10.1038/s41592-020-0821-0
pii: 10.1038/s41592-020-0821-0
pmc: PMC7332344
mid: EMS86661
doi:

Substances chimiques

Ligands 0
Lipids 0
Membrane Proteins 0
Proteome 0

Banques de données

figshare
['10.6084/m9.figshare.12021057.v1']

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

505-508

Subventions

Organisme : Wellcome Trust
ID : 104633
Pays : United Kingdom
Organisme : European Research Council
ID : 695511
Pays : International
Organisme : Medical Research Council
ID : MR/N020413/1
Pays : United Kingdom

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Auteurs

Joseph Gault (J)

Department of Chemistry, University of Oxford, Oxford, UK. joseph.gault@chem.ox.ac.uk.

Idlir Liko (I)

Department of Chemistry, University of Oxford, Oxford, UK.
OMass Therapeutics, Oxford, UK.

Michael Landreh (M)

Department of Microbiology, Tumor and Cell Biology, Biomedicum, Karolinska Institutet, Stockholm, Sweden.

Denis Shutin (D)

Department of Chemistry, University of Oxford, Oxford, UK.

Jani Reddy Bolla (JR)

Department of Chemistry, University of Oxford, Oxford, UK.

Damien Jefferies (D)

School of Chemistry, University of Southampton, Southampton, UK.

Mark Agasid (M)

Department of Chemistry, University of Oxford, Oxford, UK.

Hsin-Yung Yen (HY)

OMass Therapeutics, Oxford, UK.

Marcus J G W Ladds (MJGW)

Department of Microbiology, Tumor and Cell Biology, Biomedicum, Karolinska Institutet, Stockholm, Sweden.

David P Lane (DP)

Department of Microbiology, Tumor and Cell Biology, Biomedicum, Karolinska Institutet, Stockholm, Sweden.

Syma Khalid (S)

School of Chemistry, University of Southampton, Southampton, UK.

Christopher Mullen (C)

Thermo Fisher Scientific, San Jose, CA, USA.

Philip M Remes (PM)

Thermo Fisher Scientific, San Jose, CA, USA.

Romain Huguet (R)

Thermo Fisher Scientific, San Jose, CA, USA.

Graeme McAlister (G)

Thermo Fisher Scientific, San Jose, CA, USA.

Michael Goodwin (M)

Thermo Fisher Scientific, San Jose, CA, USA.

Rosa Viner (R)

Thermo Fisher Scientific, San Jose, CA, USA.

John E P Syka (JEP)

Thermo Fisher Scientific, San Jose, CA, USA.

Carol V Robinson (CV)

Department of Chemistry, University of Oxford, Oxford, UK. carol.robinson@chem.ox.ac.uk.

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Classifications MeSH