Activation of PXR by Alpinetin Contributes to Abrogate Chemically Induced Inflammatory Bowel Disease.
alpinetin
inflammatory bowel disease
nuclear factor-kappa B
pregnane X receptor
xenobiotics
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2020
2020
Historique:
received:
25
11
2019
accepted:
26
03
2020
entrez:
7
5
2020
pubmed:
7
5
2020
medline:
7
5
2020
Statut:
epublish
Résumé
Alpinetin is a naturally occurring flavonoid from the ginger plants. We previously reported the identification of alpinetin as a ligand of human pregnane X receptor (hPXR). The current study investigated the role of alpinetin as a putative PXR activator in ameliorating chemically induced inflammatory bowel disease (IBD). We found that oral administration of alpinetin significantly alleviated the severity of dextran sulfate sodium (DSS)-induced colitis in mice by decreasing the inflammatory infiltration, the levels of the pro-inflammatory mediators, and the PXR target genes in the colon.
Identifiants
pubmed: 32372959
doi: 10.3389/fphar.2020.00474
pmc: PMC7186371
doi:
Types de publication
Journal Article
Langues
eng
Pagination
474Informations de copyright
Copyright © 2020 Yu, Yue, Ding, Luo, Ren, Zhang, Mani, Wang and Dou.
Références
J Pharmacol Sci. 2014;124(2):180-91
pubmed: 24492412
Immunity. 2014 Aug 21;41(2):296-310
pubmed: 25065623
Drug Des Devel Ther. 2015 Dec 07;9:6343-62
pubmed: 26674743
Br J Cancer. 2010 Jun 8;102(12):1753-61
pubmed: 20531417
J Clin Invest. 2006 Aug;116(8):2280-2289
pubmed: 16841097
Drug Metab Rev. 2013 Feb;45(1):60-72
pubmed: 23330542
J Pharmacol Exp Ther. 2015 Feb;352(2):315-24
pubmed: 25472953
Gastroenterology. 2006 Feb;130(2):341-8; quiz 592
pubmed: 16472590
Am J Physiol Gastrointest Liver Physiol. 2007 Apr;292(4):G1114-22
pubmed: 17170021
PLoS One. 2012;7(7):e36075
pubmed: 22815676
Inflammation. 2012 Apr;35(2):746-57
pubmed: 21830094
Drug Metab Dispos. 2015 Aug;43(8):1181-9
pubmed: 25986850
J Nutr Biochem. 2014 Sep;25(9):923-33
pubmed: 24913217
Mol Pharmacol. 2011 Jul;80(1):124-35
pubmed: 21464197
Gastroenterology. 2004 Jul;127(1):26-40
pubmed: 15236169
Mol Med Rep. 2018 Oct;18(4):4030-4036
pubmed: 30132572
Sci Rep. 2016 Jun 20;6:28370
pubmed: 27321991
Int Immunopharmacol. 2014 Nov;23(1):170-8
pubmed: 25194678
J Pharmacol Exp Ther. 2010 Oct;335(1):32-41
pubmed: 20627999
Trends Pharmacol Sci. 2012 Jun;33(6):323-30
pubmed: 22609277
Gut. 2012 Nov;61(11):1619-35
pubmed: 22842618
Mol Endocrinol. 2008 Apr;22(4):838-57
pubmed: 18096694
Molecules. 2018 Jun 07;23(6):
pubmed: 29880739
J Pharmacol Exp Ther. 2014 Dec;351(3):559-67
pubmed: 25277138
Am J Physiol Gastrointest Liver Physiol. 2014 Jan 1;306(1):G27-36
pubmed: 24232001