Joint and Muscle Assessments of the Separate Effects of Botulinum NeuroToxin-A and Lower-Leg Casting in Children With Cerebral Palsy.
Botulinum NeuroToxin
casting
cerebral palsy
hyper-resistance
muscle length
muscle stretch reflex
spasticity
tendon length
Journal
Frontiers in neurology
ISSN: 1664-2295
Titre abrégé: Front Neurol
Pays: Switzerland
ID NLM: 101546899
Informations de publication
Date de publication:
2020
2020
Historique:
received:
02
12
2019
accepted:
09
03
2020
entrez:
7
5
2020
pubmed:
7
5
2020
medline:
7
5
2020
Statut:
epublish
Résumé
Botulinum NeuroToxin-A (BoNT-A) injections to the medial gastrocnemius (MG) and lower-leg casts are commonly combined to treat ankle equinus in children with spastic cerebral palsy (CP). However, the decomposed treatment effects on muscle or tendon structure, stretch reflexes, and joint are unknown. In this study, BoNT-A injections to the MG and casting of the lower legs were applied separately to gain insight into the working mechanisms of the isolated treatments on joint, muscle, and tendon levels. Thirty-one children with spastic CP (GMFCS I-III, age 7.4 ± 2.6 years) received either two weeks of lower-leg casts or MG BoNT-A injections. During full range of motion slow and fast passive ankle rotations, joint resistance and MG stretch reflexes were measured. MG muscle and tendon lengths were assessed at resting and at maximum dorsiflexion ankle angles using 3D-freehand ultrasound. Treatment effects were compared using non-parametric statistics. Associations between the effects on joint and muscle or tendon levels were performed using Spearman correlation coefficients (
Identifiants
pubmed: 32373040
doi: 10.3389/fneur.2020.00210
pmc: PMC7187925
doi:
Banques de données
figshare
['10.6084/m9.figshare.12009375.v1']
Types de publication
Journal Article
Langues
eng
Pagination
210Informations de copyright
Copyright © 2020 Peeters, Van Campenhout, Hanssen, Cenni, Schless, Van den Broeck, Desloovere and Bar-On.
Références
J Child Orthop. 2015 Jun;9(3):209-19
pubmed: 26108740
J Biomech. 2016 Sep 6;49(13):3004-3008
pubmed: 27515440
Comput Methods Programs Biomed. 2016 Nov;136:179-87
pubmed: 27686714
Clin Biomech (Bristol, Avon). 2013 Nov-Dec;28(9-10):1061-7
pubmed: 24210836
J Orthop Res. 2015 Jul;33(7):1039-45
pubmed: 25732238
Ultrasound Med Biol. 2018 Jan;44(1):110-118
pubmed: 29122315
Conf Proc IEEE Eng Med Biol Soc. 2009;2009:5287-90
pubmed: 19964117
Dev Med Child Neurol. 2019 Jul;61(7):783-790
pubmed: 30320442
Gait Posture. 2014 Jan;39(1):17-22
pubmed: 23791154
J Strength Cond Res. 2005 Feb;19(1):231-40
pubmed: 15705040
Front Pediatr. 2019 Aug 13;7:333
pubmed: 31456995
Brain. 2000 Aug;123 ( Pt 8):1688-702
pubmed: 10908198
J Orthop Sci. 2018 Mar;23(2):389-393
pubmed: 29146092
J Physiother. 2017 Apr;63(2):67-75
pubmed: 28433236
Int J Rehabil Res. 2004 Dec;27(4):275-81
pubmed: 15572990
Dev Med Child Neurol. 2018 Jul;60(7):672-679
pubmed: 29573407
Exerc Sport Sci Rev. 2006 Oct;34(4):154-8
pubmed: 17031252
J Child Orthop. 2013 Nov;7(5):425-33
pubmed: 24432106
Phys Ther. 1987 Feb;67(2):206-7
pubmed: 3809245
Gait Posture. 2013 May;38(1):141-7
pubmed: 23218728
Muscle Nerve. 2018 Aug;58(2):277-285
pubmed: 29572878
Eur J Paediatr Neurol. 2009 Sep;13(5):421-9
pubmed: 18977158
Comput Methods Programs Biomed. 2018 Mar;156:97-103
pubmed: 29428080
Dev Med Child Neurol. 2012 Jun;54(6):495-9
pubmed: 22364585
Paediatr Drugs. 2019 Aug;21(4):261-281
pubmed: 31257556
Disabil Rehabil. 2013 Apr;35(7):596-605
pubmed: 22928803
Dev Med Child Neurol. 2018 Nov;60(11):1165-1171
pubmed: 30151852
Nat Rev Dis Primers. 2016 Jan 07;2:15082
pubmed: 27188686
Dev Med Child Neurol. 2007 Jan;49(1):56-61
pubmed: 17209978
J Appl Physiol (1985). 2011 Aug;111(2):435-42
pubmed: 21596920
Arch Phys Med Rehabil. 1996 May;77(5):487-92
pubmed: 8629926
Gait Posture. 2015 Jun;42(1):7-15
pubmed: 25936760
Med Hypotheses. 2017 Nov;109:65-69
pubmed: 29150297
BMC Musculoskelet Disord. 2013 Dec 23;14:365
pubmed: 24364826
NeuroRehabilitation. 2014;35(1):123-9
pubmed: 24990017
Res Dev Disabil. 2013 Mar;34(3):1052-8
pubmed: 23295965
J Child Orthop. 2013 Nov;7(5):383-7
pubmed: 24432099
Am J Physiol Cell Physiol. 2018 Aug 1;315(2):C247-C257
pubmed: 29694232
Dev Med Child Neurol. 2013 Sep;55(9):813-20
pubmed: 23789782
Yonsei Med J. 2014 Sep;55(5):1406-12
pubmed: 25048504