Problem Formulation for Off-Target Effects of Externally Applied Double-Stranded RNA-Based Products for Pest Control.
acceptable risk
decision-making
hypothesis testing
problem formulation
targeted risk assessment
Journal
Frontiers in plant science
ISSN: 1664-462X
Titre abrégé: Front Plant Sci
Pays: Switzerland
ID NLM: 101568200
Informations de publication
Date de publication:
2020
2020
Historique:
received:
16
12
2019
accepted:
24
03
2020
entrez:
7
5
2020
pubmed:
7
5
2020
medline:
7
5
2020
Statut:
epublish
Résumé
Externally applied dsRNA-based biocontrol products may lead to off-target degradation of messenger RNA in target and non-target organisms. For the purposes of regulatory risk assessment of such products, producing a comprehensive catalog of any off-target effects using profiling methods is unnecessary and would be ineffective in supporting decision-making. Instead, problem formulation should derive criteria that indicate acceptable risk and devise a plan to test the hypothesis that the product meets those criteria. The key to effective risk assessment of dsRNA-based biocontrols is determining whether their properties indicate acceptable or unacceptable risk, not whether they arise from on- or off-target effects of dsRNA.
Identifiants
pubmed: 32373142
doi: 10.3389/fpls.2020.00424
pmc: PMC7179753
doi:
Types de publication
Journal Article
Langues
eng
Pagination
424Informations de copyright
Copyright © 2020 Raybould and Burns.
Références
GM Crops Food. 2015;6(3):167-82
pubmed: 26177011
Environ Int. 2013 May;55:43-55
pubmed: 23523853
GM Crops Food. 2019;10(2):63-76
pubmed: 31184249
Front Bioeng Biotechnol. 2018 Apr 10;6:43
pubmed: 29755975
Trends Ecol Evol. 2007 Apr;22(4):192-7
pubmed: 17174005
Regul Toxicol Pharmacol. 2016 Nov;81:77-88
pubmed: 27494948
Regul Toxicol Pharmacol. 2015 Nov;73(2):671-80
pubmed: 26361858
Plant Cell Rep. 2019 Dec;38(12):1449-1463
pubmed: 31350570
Nat Biotechnol. 2008 Feb;26(2):203-8
pubmed: 18259178
Regul Toxicol Pharmacol. 2016 Nov;81:57-68
pubmed: 27436086
Environ Toxicol Chem. 2017 Mar;36(3):727-734
pubmed: 27530554
Environ Biosafety Res. 2006 Jul-Sep;5(3):119-25
pubmed: 17445509
Toxicol Lett. 2008 Aug 15;180(2):137-50
pubmed: 18585444
Trends Biotechnol. 2006 Aug;24(8):343-6
pubmed: 16782220
Cold Spring Harb Perspect Biol. 2019 Mar 1;11(3):
pubmed: 30824577
Front Physiol. 2016 Nov 17;7:553
pubmed: 27909411
Sci Total Environ. 2018 Sep 1;635:687-698
pubmed: 29680759
Pest Manag Sci. 2017 Sep;73(9):1883-1899
pubmed: 28195683
Pest Manag Sci. 2018 Jun;74(6):1239-1250
pubmed: 29194942
Environ Int. 2011 Oct;37(7):1285-93
pubmed: 21624662
Nat Biotechnol. 2003 Sep;21(9):1003-9
pubmed: 12949561
Plant Biotechnol J. 2017 Oct;15(10):1264-1272
pubmed: 28218975
J Appl Genet. 2006;47(4):277-86
pubmed: 17132892
GM Crops Food. 2014 Jan-Mar;5(1):44-57
pubmed: 24499745
Pest Manag Sci. 2019 Oct;75(10):2652-2662
pubmed: 30729648
Phytopathology. 2017 Jun;107(6):624-634
pubmed: 28409526
Int J Environ Res Public Health. 2011 May;8(5):1402-19
pubmed: 21655127
Trends Plant Sci. 2018 Dec;23(12):1047-1056
pubmed: 30361071
Front Physiol. 2018 Apr 04;9:316
pubmed: 29670535
New Phytol. 2016 Aug;211(3):1008-19
pubmed: 27030513
PLoS One. 2014 Mar 27;9(3):e93155
pubmed: 24676387
Regul Toxicol Pharmacol. 2019 Feb;101:187-193
pubmed: 30513358
Nat Methods. 2006 Oct;3(10):833-8
pubmed: 16964256