Risk Assessment Considerations for Genetically Modified RNAi Plants: EFSA's Activities and Perspective.
DvSnf7
RNAi
crops
dsRNA
gene silencing
genetically modified organisms
off-target
risk assessment
Journal
Frontiers in plant science
ISSN: 1664-462X
Titre abrégé: Front Plant Sci
Pays: Switzerland
ID NLM: 101568200
Informations de publication
Date de publication:
2020
2020
Historique:
received:
21
12
2019
accepted:
25
03
2020
entrez:
7
5
2020
pubmed:
7
5
2020
medline:
7
5
2020
Statut:
epublish
Résumé
Genetically modified plants (GMPs) intended for market release can be designed to induce "gene silencing" through RNA interference (RNAi). The European Food Safety Authority (EFSA) and other international risk assessment bodies/regulatory agencies have taken several actions to determine whether the existing risk assessment approaches for GMPs are appropriate for the risk assessment of RNAi-based GMPs or require complementary or alternative approaches. To our knowledge, at the international level, no dedicated guidelines have been developed for the risk assessment and regulation of RNAi-based GMPs, confirming that existing science-based risk assessment approaches for GMPs are generally considered suitable for RNAi-based GMPs. However, some specificities have been identified for the risk assessment of RNAi-based GMPs. Here, we report on some of these specificities as identified and addressed by the EFSA GMO Panel for the molecular characterisation, food/feed safety assessment and environmental risk assessment of RNAi-based GMPs, using the DvSnf7 dsRNA-expressing maize MON87411 as a case study.
Identifiants
pubmed: 32373145
doi: 10.3389/fpls.2020.00445
pmc: PMC7186845
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
445Informations de copyright
Copyright © 2020 Papadopoulou, Devos, Álvarez-Alfageme, Lanzoni and Waigmann.
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