The Role of Genetic Variation of BMI, Body Composition, and Fat Distribution for Mental Traits and Disorders: A Look-Up and Mendelian Randomization Study.
GWAS
Mendelian randomization
abdominal obesity
body composition
body mass index
genetic overlap
mental disorders
mental traits
Journal
Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621
Informations de publication
Date de publication:
2020
2020
Historique:
received:
26
08
2019
accepted:
26
03
2020
entrez:
7
5
2020
pubmed:
7
5
2020
medline:
7
5
2020
Statut:
epublish
Résumé
Anthropometric traits and mental disorders or traits are known to be associated clinically and to show genetic overlap. We aimed to identify genetic variants with relevance for mental disorders/traits and either (i) body mass index (or obesity), (ii) body composition, (and/or) (iii) body fat distribution. We performed a look-up analysis of 1,005 genome-wide significant SNPs for BMI, body composition, and body fat distribution in 15 mental disorders/traits. We identified 40 independent loci with one or more SNPs fulfilling our threshold significance criterion (
Identifiants
pubmed: 32373164
doi: 10.3389/fgene.2020.00373
pmc: PMC7186862
doi:
Types de publication
Journal Article
Langues
eng
Pagination
373Informations de copyright
Copyright © 2020 Peters, Nüllig, Antel, Naaresh, Laabs, Tegeler, Amhaouach, Libuda, Hinney and Hebebrand.
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