Coronary Artery Spasm: The Interplay Between Endothelial Dysfunction and Vascular Smooth Muscle Cell Hyperreactivity.
Coronary artery spasm
angina pectoris
endothelial dysfunction
unobstructed coronary arteries
vascular smooth muscle cell hyperreactivity
Journal
European cardiology
ISSN: 1758-3764
Titre abrégé: Eur Cardiol
Pays: England
ID NLM: 101574780
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
received:
09
12
2019
accepted:
06
01
2020
entrez:
7
5
2020
pubmed:
7
5
2020
medline:
7
5
2020
Statut:
epublish
Résumé
Patients with angina pectoris, the cardinal symptom of myocardial ischaemia, yet without significant flow-limiting epicardial artery stenosis represent a diagnostic and therapeutic challenge. Coronary artery spasm (CAS) is an established cause for anginal chest pain in patients with angiographically unobstructed coronary arteries. CAS may occur at the epicardial level and/or in the microvasculature. Although the underlying pathophysiological mechanisms of CAS are still largely unclear, endothelial dysfunction and vascular smooth muscle cell (VSMC) hyperreactivity seem to be involved as major players, although their contribution to induce CAS is still seen as controversial. This article will look at the role and possible mechanistic interplay between an impaired endothelial and VSMC function in the pathogenesis of CAS.
Identifiants
pubmed: 32373185
doi: 10.15420/ecr.2019.20
pmc: PMC7199189
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
e12Informations de copyright
Copyright © 2020, Radcliffe Cardiology.
Déclaration de conflit d'intérêts
Disclosure: The authors have no conflicts of interest to declare.
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