The role of transporters in cancer redox homeostasis and cross-talk with nanomedicines.
Cancer metabolism
Membrane transporter
Nanomedicine
ROS, Redox homeostasis
xCT/SLC7A11
Journal
Asian journal of pharmaceutical sciences
ISSN: 2221-285X
Titre abrégé: Asian J Pharm Sci
Pays: Netherlands
ID NLM: 101535338
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
31
10
2019
revised:
03
12
2019
accepted:
12
02
2020
entrez:
7
5
2020
pubmed:
7
5
2020
medline:
7
5
2020
Statut:
ppublish
Résumé
Tumor cell usually exhibits high levels of reactive oxygen species and adaptive antioxidant system due to the metabolic, genetic, and microenvironment-associated alterations. The altered redox homeostasis can promote tumor progression, development, and treatment resistance. Several membrane transporters are involved in the resetting redox homeostasis and play important roles in tumor progression. Therefore, targeting the involved transporters to disrupt the altered redox balance emerges as a viable strategy for cancer therapy. In addition, nanomedicines have drawn much attention in the past decades. Using nanomedicines to target or reset the redox homeostasis alone or combined with other therapies has brought convincing data in cancer treatment. In this review, we will introduce the altered redox balance in cancer metabolism and involved transporters, and highlight the recent advancements of redox-modulating nanomedicines for cancer treatment.
Identifiants
pubmed: 32373196
doi: 10.1016/j.ajps.2020.02.001
pii: S1818-0876(19)31354-6
pmc: PMC7193452
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
145-157Informations de copyright
© 2020 Shenyang Pharmaceutical University. Published by Elsevier B.V.
Déclaration de conflit d'intérêts
The authors report no conflict of interest.
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