Toward clinical understanding of aristolochic acid upper-tract urothelial carcinoma.
Journal
Theranostics
ISSN: 1838-7640
Titre abrégé: Theranostics
Pays: Australia
ID NLM: 101552395
Informations de publication
Date de publication:
2020
2020
Historique:
received:
30
03
2020
accepted:
13
04
2020
entrez:
7
5
2020
pubmed:
7
5
2020
medline:
14
5
2021
Statut:
epublish
Résumé
A cluster of patients poisoned by herbal medicine in the 1990s revealed that aristolochic acid (AA) causes kidney failure and upper tract urothelial carcinoma (UTUC). Recent research demonstrated that this was not an isolated incident; on the contrary, AA exposure is widespread in East Asia. This editorial highlights research by Lu and colleagues that investigates clinical characteristics of AA and non-AA UTUCs from 90 patients in Beijing based on the AA mutational signature. The study also detected AA mutations in non-tumor tissue of AA exposed patients and showed that AA mutations can be detected in urine, which might form the basis for non-invasive tests for AA exposure.
Identifiants
pubmed: 32373232
doi: 10.7150/thno.46489
pii: thnov10p5578
pmc: PMC7196294
doi:
Substances chimiques
Aristolochic Acids
0
Mutagens
0
Neoplasm Proteins
0
aristolochic acid I
94218WFP5T
Types de publication
Editorial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5578-5580Informations de copyright
© The author(s).
Déclaration de conflit d'intérêts
Competing Interests: The authors have declared that no competing interest exists.
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