Characterization of IL-21-expressing recombinant hepatitis B virus (HBV) as a therapeutic agent targeting persisting HBV infection.

Animals DNA, Viral / genetics Disease Models, Animal Genetic Vectors / administration & dosage Hepatitis / genetics Hepatitis B virus / genetics Humans Interleukins / administration & dosage Male Mice Mice, Inbred BALB C
HBV clearance hepatitis B virus interleukin 21 recombinant HBV vector superinfection

Journal

Theranostics
ISSN: 1838-7640
Titre abrégé: Theranostics
Pays: Australia
ID NLM: 101552395

Informations de publication

Date de publication:
2020
Historique:
received: 08 02 2020
accepted: 09 04 2020
entrez: 7 5 2020
pubmed: 7 5 2020
medline: 14 5 2021
Statut: epublish

Résumé

Chronic infection by hepatitis B virus (HBV) is associated with high risks of liver fibrosis, cirrhosis and hepatocellular carcinoma. In mouse models of HBV persistence, interleukin 21 (IL-21) has been identified as a potent inducer of viral clearance. Strict hepatotropism makes recombinant HBV (rHBV) vectors ideal for liver-targeting gene delivery. Previously, we established an rHBV vector termed 5c3c, which is highly replicative by itself, but requires HBV envelope proteins provided

Identifiants

DOI: 10.7150/thno.44715 PMID: 32373234 PMC: PMC7196313
pubmed: 32373234
doi: 10.7150/thno.44715
pii: thnov10p5600
pmc: PMC7196313
doi:

Substances chimiques

DNA, Viral 0
Interleukins 0
interleukin-21 MKM3CA6LT1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

5600-5612

Informations de copyright

© The author(s).

Déclaration de conflit d'intérêts

Competing Interests: The authors have declared that no competing interest exists.

Références

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Auteurs

Zhongliang Shen (Z)

Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai 200040, People's Republic of China.
Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Department of Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, People's Republic of China.

Jingwen Wu (J)

Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai 200040, People's Republic of China.

Zixiang Gao (Z)

Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Department of Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, People's Republic of China.

Jingyu Wang (J)

Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai 200040, People's Republic of China.

Haoxiang Zhu (H)

Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai 200040, People's Republic of China.

Richen Mao (R)

Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai 200040, People's Republic of China.

Xuanyi Wang (X)

Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Department of Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, People's Republic of China.
Key Laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, People's Republic of China.

Jiming Zhang (J)

Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai 200040, People's Republic of China.
Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Department of Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, People's Republic of China.

Youhua Xie (Y)

Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Department of Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, People's Republic of China.

Jing Liu (J)

Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Department of Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, People's Republic of China.
Key Laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, People's Republic of China.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Characterization of IL-21-expressing...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › ADN viral › Characterization of IL-21-expressing...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Characterization of IL-21-expressing...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Vecteurs génétiques › Characterization of IL-21-expressing...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Hépatite › Characterization of IL-21-expressing...
questionsmedicales.fr › Virus › Virus de l'hépatite › Hepadnaviridae › Orthohepadnavirus › Virus de l'hépatite B › Characterization of IL-21-expressing...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Characterization of IL-21-expressing...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Characterization of IL-21-expressing...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Characterization of IL-21-expressing...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée BALB C › Characterization of IL-21-expressing...