A case of pulmonary arterial hypertension with chronic hepatitis that resulted in hepatosplenomegaly after administration of prostaglandin I2.
Hepatosplenomegaly
Prostaglandin I2
Pulmonary arterial hypertension
Journal
Journal of cardiology cases
ISSN: 1878-5409
Titre abrégé: J Cardiol Cases
Pays: Japan
ID NLM: 101549579
Informations de publication
Date de publication:
May 2020
May 2020
Historique:
received:
30
03
2019
revised:
29
11
2019
accepted:
05
01
2020
entrez:
7
5
2020
pubmed:
7
5
2020
medline:
7
5
2020
Statut:
epublish
Résumé
The prognosis of pulmonary arterial hypertension (PAH) has significantly improved over the past two decades due to advances in medications, including pulmonary vasodilators. However, the side effects of these drugs remain problematic in some patients. A 51-year-old woman with chronic hepatitis C was diagnosed with PAH 7 years before presenting to our hospital. She was unable to continue her treatment with pulmonary vasodilators due to various side effects. She had a World Health Organization functional class of IV and was started on continuous infusion of prostaglandin I2 (PGI2). This therapy improved her symptoms, including dyspnea and fatigue. However, she began to complain of abdominal distension after 4 months of PGI2 therapy. Computed tomography showed significant hepatosplenomegaly. Her abdominal distension improved slightly after decreasing PGI2 treatment, but her dyspnea on exertion was exacerbated. She died 12 years after diagnosis of PAH due to uncontrollable heart failure. Here, we describe a rare case of PAH with hepatosplenomegaly after administration of PGI2. <
Identifiants
pubmed: 32373243
doi: 10.1016/j.jccase.2020.01.001
pii: S1878-5409(20)30001-3
pmc: PMC7195569
doi:
Types de publication
Case Reports
Langues
eng
Pagination
182-185Informations de copyright
© 2020 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.
Références
J Cardiol. 2014 Oct;64(4):243-9
pubmed: 25082294
Pulm Circ. 2017 Jul-Sep;7(3):598-608
pubmed: 28632002
Hepatology. 2010 Apr;51(4):1445-9
pubmed: 20077563
Br J Pharmacol. 1995 Dec;116(7):2828-37
pubmed: 8680713
World J Hepatol. 2015 Mar 27;7(3):607-15
pubmed: 25848485
Pharmacol Rev. 2012 Jul;64(3):540-82
pubmed: 22679221
Eur Respir J. 2015 Oct;46(4):903-75
pubmed: 26318161
Liver Transpl Surg. 1999 Sep;5(5):362-5
pubmed: 10477835