The Diabetes Risk and Determinants of Transition from Metabolically Healthy to Unhealthy Phenotypes in 49,702 Older Adults: 4-Year Cohort Study.
Journal
Obesity (Silver Spring, Md.)
ISSN: 1930-739X
Titre abrégé: Obesity (Silver Spring)
Pays: United States
ID NLM: 101264860
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
20
11
2019
revised:
01
02
2020
accepted:
25
02
2020
pubmed:
7
5
2020
medline:
22
9
2020
entrez:
7
5
2020
Statut:
ppublish
Résumé
This study aimed to assess whether metabolically healthy obesity (MHO) increases the risk of diabetes and to explore how the occurrence of metabolic disorders affects the risk of diabetes and which factors determine metabolic health. This study examined 49,702 older people without diabetes via the Binhai Health Screening Program in Tianjin. Compared with individuals with metabolic health and normal weight, the risk of diabetes was increased in older adults with MHO (hazard ratio [HR]: 1.786, 95% CI: 1.407-2.279) but was not significantly increased when metabolic health was characterized by the absence of metabolic abnormalities. The older adults who were initially affected by MHO and then converted to having an unhealthy phenotype had a higher diabetes risk than older individuals with stable and healthy normal weight (HR: 3.727, 95% CI: 2.721-5.105). Waist circumference was an independent predictor of the transition from a metabolically healthy status to an unhealthy status in all BMI categories (odds ratio: 1.059, 95% CI: 1.026-1.032). The MHO phenotype was associated with an increased incidence of diabetes in older adults. The presence of metabolic disorders in the group with MHO was associated with an increased diabetes risk and was predicted by the waist circumference at baseline.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1141-1148Subventions
Organisme : Tianjin Science and Technology Support Project
ID : 17JCYBJC27000
Pays : International
Organisme : National Natural Science Foundation of China
ID : 81200611
Pays : International
Organisme : National Natural Science Foundation of China
ID : 81600643
Pays : International
Organisme : National Natural Science Foundation of China
ID : 91746205
Pays : International
Organisme : the Tianjin Health Industry Key Research Projects
ID : 15KG101
Pays : International
Organisme : Key Projects of Tianjin Natural Science Foundation
ID : 18JCZDJC32900
Pays : International
Organisme : Postdoctoral fund project of the Ministry of Education, China
ID : 2013M530881
Pays : International
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2020 The Obesity Society.
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