Secreted Phospholipase PLA2G2D Contributes to Metabolic Health by Mobilizing ω3 Polyunsaturated Fatty Acids in WAT.

Adipocytes / metabolism Adipose Tissue, Brown / metabolism Adipose Tissue, White / metabolism Animals Energy Metabolism Fatty Acids, Omega-3 / metabolism Fatty Acids, Unsaturated / metabolism Group II Phospholipases A2 / metabolism Inflammation / metabolism Macrophages / metabolism Mice Obesity / metabolism Phospholipases / metabolism Thermogenesis / physiology
beige adipocyte inflammation lipidomics macrophage metabolic health obesity phospholipase A(2) polyunsaturated fatty acid thermogenesis

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
05 05 2020
Historique:
received: 04 01 2019
revised: 18 11 2019
accepted: 07 04 2020
entrez: 7 5 2020
pubmed: 7 5 2020
medline: 4 6 2021
Statut: ppublish

Résumé

Polyunsaturated fatty acids (PUFAs) confer health benefits by preventing inflammation and obesity and by increasing thermogenesis in brown and beige adipocytes. As well as being supplied exogenously as nutrients, PUFAs are largely stored in membrane glycerophospholipids and released by phospholipase A

Identifiants

DOI: 10.1016/j.celrep.2020.107579 PMID: 32375030
pubmed: 32375030
pii: S2211-1247(20)30528-3
doi: 10.1016/j.celrep.2020.107579
pii:
doi:

Substances chimiques

Fatty Acids, Omega-3 0
Fatty Acids, Unsaturated 0
Phospholipases EC 3.1.-
Group II Phospholipases A2 EC 3.1.1.4
Pla2g2d protein, mouse EC 3.1.1.4

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

107579

Informations de copyright

Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Interests The authors declare no competing interests.

Auteurs

Hiroyasu Sato (H)

Laboratory of Microenvironmental and Metabolic Health Science, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan; Lipid Metabolism Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan.

Yoshitaka Taketomi (Y)

Laboratory of Microenvironmental and Metabolic Health Science, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan; Lipid Metabolism Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan.

Yoshimi Miki (Y)

Laboratory of Microenvironmental and Metabolic Health Science, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan; Lipid Metabolism Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan.

Remi Murase (R)

Laboratory of Microenvironmental and Metabolic Health Science, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan; Lipid Metabolism Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan.

Kei Yamamoto (K)

Lipid Metabolism Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan; Department of Bioscience and Bioindustry, Tokushima University, Tokushima 770-8506, Japan.

Makoto Murakami (M)

Laboratory of Microenvironmental and Metabolic Health Science, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan; Lipid Metabolism Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan; AMED-CREST, Japan Agency for Medical Research and Development, Tokyo 100-0004, Japan; FORCE, Japan Agency for Medical Research and Development, Tokyo 100-0004, Japan. Electronic address: makmurak@m.u-tokyo.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Adipocytes › Secreted Phospholipase PLA2G2D Contributes to...
questionsmedicales.fr › Tissus › Tissu conjonctif › Tissu adipeux › Tissu adipeux brun › Secreted Phospholipase PLA2G2D Contributes to...
questionsmedicales.fr › Tissus › Tissu conjonctif › Tissu adipeux › Tissu adipeux blanc › Secreted Phospholipase PLA2G2D Contributes to...
questionsmedicales.fr › Eucaryotes › Animaux › Secreted Phospholipase PLA2G2D Contributes to...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Secreted Phospholipase PLA2G2D Contributes to...
questionsmedicales.fr › Lipides › Huiles › Huiles de poisson › Acides gras omega-3 › Secreted Phospholipase PLA2G2D Contributes to...
questionsmedicales.fr › Lipides › Acides gras › Acides gras insaturés › Secreted Phospholipase PLA2G2D Contributes to...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Phospholipases A › Phospholipases A2 › Secretory Phospholipases A2 › Group II Phospholipases A2 › Secreted Phospholipase PLA2G2D Contributes to...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Secreted Phospholipase PLA2G2D Contributes to...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Secreted Phospholipase PLA2G2D Contributes to...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Secreted Phospholipase PLA2G2D Contributes to...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Obésité › Secreted Phospholipase PLA2G2D Contributes to...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Phosphodiesterases › Phospholipases › Secreted Phospholipase PLA2G2D Contributes to...
questionsmedicales.fr › Phénomènes biologiques › Adaptation biologique › Adaptation physiologique › Régulation de la température corporelle › Thermogenèse › Secreted Phospholipase PLA2G2D Contributes to...