Lipids and Lipid-Processing Pathways in Drug Delivery and Therapeutics.
fatty acid
glyceride
lipid
oral drug absorption
phospholipase A2 (PLA2)
phospholipid
prodrug
steroid
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
04 May 2020
04 May 2020
Historique:
received:
13
04
2020
revised:
28
04
2020
accepted:
02
05
2020
entrez:
8
5
2020
pubmed:
8
5
2020
medline:
7
2
2021
Statut:
epublish
Résumé
The aim of this work is to analyze relevant endogenous lipid processing pathways, in the context of the impact that lipids have on drug absorption, their therapeutic use, and utilization in drug delivery. Lipids may serve as biomarkers of some diseases, but they can also provide endogenous therapeutic effects for certain pathological conditions. Current uses and possible clinical benefits of various lipids (fatty acids, steroids, triglycerides, and phospholipids) in cancer, infectious, inflammatory, and neurodegenerative diseases are presented. Lipids can also be conjugated to a drug molecule, accomplishing numerous potential benefits, one being the improved treatment effect, due to joined influence of the lipid carrier and the drug moiety. In addition, such conjugates have increased lipophilicity relative to the parent drug. This leads to improved drug pharmacokinetics and bioavailability, the ability to join endogenous lipid pathways and achieve drug targeting to the lymphatics, inflamed tissues in certain autoimmune diseases, or enable overcoming different barriers in the body. Altogether, novel mechanisms of the lipid role in diseases are constantly discovered, and new ways to exploit these mechanisms for the optimal drug design that would advance different drug delivery/therapy aspects are continuously emerging.
Identifiants
pubmed: 32375338
pii: ijms21093248
doi: 10.3390/ijms21093248
pmc: PMC7247327
pii:
doi:
Substances chimiques
Drug Carriers
0
Lipids
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : United States-Israel Binational Science Foundation
ID : 2015365
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