Design of Calcium-Binding Proteins to Sense Calcium.

Animals Binding Sites Biosensing Techniques Calcium / chemistry Calcium-Binding Proteins / chemistry Humans Models, Molecular Protein Binding Protein Conformation Protein Engineering Protein Folding Research
CaBP fusion protein protein engineering rational design synthesis

Journal

Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009

Informations de publication

Date de publication:
04 May 2020
Historique:
received: 17 04 2020
revised: 27 04 2020
accepted: 28 04 2020
entrez: 8 5 2020
pubmed: 8 5 2020
medline: 12 2 2021
Statut: epublish

Résumé

Calcium controls numerous biological processes by interacting with different classes of calcium binding proteins (CaBP's), with different affinities, metal selectivities, kinetics, and calcium dependent conformational changes. Due to the diverse coordination chemistry of calcium, and complexity associated with protein folding and binding cooperativity, the rational design of CaBP's was anticipated to present multiple challenges. In this paper we will first discuss applications of statistical analysis of calcium binding sites in proteins and subsequent development of algorithms to predict and identify calcium binding proteins. Next, we report efforts to identify key determinants for calcium binding affinity, cooperativity and calcium dependent conformational changes using grafting and protein design. Finally, we report recent advances in designing protein calcium sensors to capture calcium dynamics in various cellular environments.

Identifiants

DOI: 10.3390/molecules25092148 PMID: 32375353 PMC: PMC7248937
pubmed: 32375353
pii: molecules25092148
doi: 10.3390/molecules25092148
pmc: PMC7248937
pii:
doi:

Substances chimiques

Calcium-Binding Proteins 0
Calcium SY7Q814VUP

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Shen Tang (S)

Department of Chemistry, Center for Diagnostics and Therapeutics and Advanced Translational Imaging Facility, Georgia State University, Atlanta, GA 30303, USA.

Xiaonan Deng (X)

Department of Chemistry, Center for Diagnostics and Therapeutics and Advanced Translational Imaging Facility, Georgia State University, Atlanta, GA 30303, USA.

Jie Jiang (J)

Department of Chemistry, Center for Diagnostics and Therapeutics and Advanced Translational Imaging Facility, Georgia State University, Atlanta, GA 30303, USA.

Michael Kirberger (M)

School of Science and Technology, Georgia Gwinnett College, Lawrenceville, GA 30043, USA.

Jenny J Yang (JJ)

Department of Chemistry, Center for Diagnostics and Therapeutics and Advanced Translational Imaging Facility, Georgia State University, Atlanta, GA 30303, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Design of Calcium-Binding Proteins to Sense Calcium.
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › Design of Calcium-Binding Proteins to Sense Calcium.
questionsmedicales.fr › Techniques d'investigation › Techniques de sonde moléculaire › Techniques de biocapteur › Design of Calcium-Binding Proteins to Sense Calcium.
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › Design of Calcium-Binding Proteins to Sense Calcium.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Protéines de liaison au calcium › Design of Calcium-Binding Proteins to Sense Calcium.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Design of Calcium-Binding Proteins to Sense Calcium.
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › Design of Calcium-Binding Proteins to Sense Calcium.
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Design of Calcium-Binding Proteins to Sense Calcium.
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Design of Calcium-Binding Proteins to Sense Calcium.
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Génie génétique › Ingénierie des protéines › Design of Calcium-Binding Proteins to Sense Calcium.
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Pliage des protéines › Design of Calcium-Binding Proteins to Sense Calcium.
questionsmedicales.fr › Disciplines des sciences naturelles › Science › Recherche › Design of Calcium-Binding Proteins to Sense Calcium.