Recent increase in non-tuberculous mycobacterial infection in patients with connective tissue diseases in Japan.

Adult Connective Tissue Diseases / complications Humans Japan / epidemiology Mycobacterium Infections, Nontuberculous / epidemiology Mycobacterium avium Complex Nontuberculous Mycobacteria Retrospective Studies
Connective tissue diseases Mycobacterium avium complex Mycobacterium xenopi Non-tuberculous mycobacteria

Journal

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
ISSN: 1437-7780
Titre abrégé: J Infect Chemother
Pays: Netherlands
ID NLM: 9608375

Informations de publication

Date de publication:
Sep 2020
Historique:
received: 20 12 2019
revised: 05 04 2020
accepted: 13 04 2020
pubmed: 8 5 2020
medline: 25 6 2021
entrez: 8 5 2020
Statut: ppublish

Résumé

Non-tuberculous mycobacterial (NTM) infection is currently a growing health concern due to the increasing incidence and the need for prolonged therapy. In patients with connective tissue diseases, use of immunosuppressants may lead to an increased risk of NTM infection. However, few studies have examined the recent incidence of NTM infection among connective tissue diseases patients. This study investigated recent trends in NTM infection among connective tissue diseases patients. We included adult patients from whose cultures NTM were isolated between January 2009 and October 2017 in our hospital. By reviewing their medical records, connective tissue diseases patients were identified. Types of connective tissue disease, NTM species, and treatment of NTM infection were extracted. NTM was isolated from 657 patients during the period. Among these, 24 patients had connective tissue diseases. The number and rate of NTM isolates from connective tissue diseases patients increased during the period, with 4 patients 2009 to 2012 (1.9%), and 20 patients from 2013 to 2017 (3.3%; P = 0.04). The proportion of Mycobacterium avium complex (MAC) to total NTM tended to be lower among connective tissue diseases patients (58.3%) than among non-connective tissue disease-patients (72.8%), but the difference was not significant (P = 0.20). Mycobacterium xenopi was significantly more frequent in connective tissue disease patients than in non-connective tissue diseases patients (P < 0.01). The recent increase in the incidence of NTM infections in connective tissue diseases patients was larger than that in the total population. NTM species other than MAC were isolated from connective tissue diseases patients.

Sections du résumé

BACKGROUND BACKGROUND
Non-tuberculous mycobacterial (NTM) infection is currently a growing health concern due to the increasing incidence and the need for prolonged therapy. In patients with connective tissue diseases, use of immunosuppressants may lead to an increased risk of NTM infection. However, few studies have examined the recent incidence of NTM infection among connective tissue diseases patients. This study investigated recent trends in NTM infection among connective tissue diseases patients.
METHODS METHODS
We included adult patients from whose cultures NTM were isolated between January 2009 and October 2017 in our hospital. By reviewing their medical records, connective tissue diseases patients were identified. Types of connective tissue disease, NTM species, and treatment of NTM infection were extracted.
RESULTS RESULTS
NTM was isolated from 657 patients during the period. Among these, 24 patients had connective tissue diseases. The number and rate of NTM isolates from connective tissue diseases patients increased during the period, with 4 patients 2009 to 2012 (1.9%), and 20 patients from 2013 to 2017 (3.3%; P = 0.04). The proportion of Mycobacterium avium complex (MAC) to total NTM tended to be lower among connective tissue diseases patients (58.3%) than among non-connective tissue disease-patients (72.8%), but the difference was not significant (P = 0.20). Mycobacterium xenopi was significantly more frequent in connective tissue disease patients than in non-connective tissue diseases patients (P < 0.01).
CONCLUSION CONCLUSIONS
The recent increase in the incidence of NTM infections in connective tissue diseases patients was larger than that in the total population. NTM species other than MAC were isolated from connective tissue diseases patients.

Identifiants

DOI: 10.1016/j.jiac.2020.04.013 PMID: 32376161
pubmed: 32376161
pii: S1341-321X(20)30137-9
doi: 10.1016/j.jiac.2020.04.013
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

941-945

Informations de copyright

Copyright © 2020 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest None.

Auteurs

Takatoshi Kitazawa (T)

Department of Internal Medicine, Teikyo University, 2-11-1, Kaga, Itabashi-ku, Tokyo, Japan. Electronic address: tkitazaw@med.teikyo-u.ac.jp.

Yusuke Yoshino (Y)

Department of Internal Medicine, Teikyo University, 2-11-1, Kaga, Itabashi-ku, Tokyo, Japan.

Kurumi Asako (K)

Department of Internal Medicine, Teikyo University, 2-11-1, Kaga, Itabashi-ku, Tokyo, Japan.

Hirotoshi Kikuchi (H)

Department of Internal Medicine, Teikyo University, 2-11-1, Kaga, Itabashi-ku, Tokyo, Japan.

Hajime Kono (H)

Department of Internal Medicine, Teikyo University, 2-11-1, Kaga, Itabashi-ku, Tokyo, Japan.

Yasuo Ota (Y)

Department of Internal Medicine, Teikyo University, 2-11-1, Kaga, Itabashi-ku, Tokyo, Japan; National Hospital Organization Higashisaitama Hospital, Hasuda, 4147, Kurohama, Saitama, Japan.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Recent increase in non-tuberculous...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies du tissu conjonctif › Recent increase in non-tuberculous...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Recent increase in non-tuberculous...
questionsmedicales.fr › Régions géographiques › Iles › Japon › Recent increase in non-tuberculous...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram positif › Infections à Actinomycetales › Infections à Mycobacterium › Infections à mycobactéries non tuberculeuses › Recent increase in non-tuberculous...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets asporogènes à Gram positif › Bâtonnets asporogènes réguliers à Gram positif › Mycobacteriaceae › Mycobacterium › Mycobactéries non tuberculeuses › Complexe Mycobacterium avium › Recent increase in non-tuberculous...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets asporogènes à Gram positif › Bâtonnets asporogènes réguliers à Gram positif › Mycobacteriaceae › Mycobacterium › Mycobactéries non tuberculeuses › Recent increase in non-tuberculous...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Recent increase in non-tuberculous...