Viral kinetics of SARS-CoV-2 in asymptomatic carriers and presymptomatic patients.
Asymptomatic carrier
COVID-19
Isolation
Presymptomatic
Viral kinetics
Journal
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
ISSN: 1878-3511
Titre abrégé: Int J Infect Dis
Pays: Canada
ID NLM: 9610933
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
16
04
2020
accepted:
28
04
2020
pubmed:
8
5
2020
medline:
24
6
2020
entrez:
8
5
2020
Statut:
ppublish
Résumé
From a total of 71 laboratory-confirmed cases, three presymptomatic patients and 10 patients with entirely asymptomatic infections were identified. In two of the three incubation period patients, the viral titer in the presymptomatic period was very high (Ct value<20). The median number of days to first negative RT-PCR in the asymptomatic carriers was 4.5 (range 2.5-9), and all asymptomatic carriers reached a first RT-PCR Ct>35 within 14 days after diagnosis. Patients who have COVID-19 may already be infectious before there are symptoms, and 14 days of isolation after diagnosis may be sufficient in entirely asymptomatic cases.
Identifiants
pubmed: 32376309
pii: S1201-9712(20)30299-X
doi: 10.1016/j.ijid.2020.04.083
pmc: PMC7196533
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
441-443Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.
Références
J Korean Med Sci. 2020 Apr 06;35(13):e140
pubmed: 32242347
Euro Surveill. 2020 Mar;25(10):
pubmed: 32183930
Lancet. 2020 Feb 22;395(10224):565-574
pubmed: 32007145
Science. 2003 Jun 20;300(5627):1966-70
pubmed: 12766207
Int J Infect Dis. 2020 Jun;95:174-175
pubmed: 32251796
Nature. 2020 May;581(7809):465-469
pubmed: 32235945
JAMA. 2020 Apr 14;323(14):1406-1407
pubmed: 32083643