Heterogeneous nuclear ribonucleoprotein (hnRNPL) in cancer.
Alternative splicing
Heterogeneous nuclear ribonucleoprotein L (hnRNPL)
Post-transcriptional regulation
RNA binding protein
Tumorigenic
Journal
Clinica chimica acta; international journal of clinical chemistry
ISSN: 1873-3492
Titre abrégé: Clin Chim Acta
Pays: Netherlands
ID NLM: 1302422
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
28
12
2019
revised:
30
04
2020
accepted:
30
04
2020
pubmed:
8
5
2020
medline:
14
1
2021
entrez:
8
5
2020
Statut:
ppublish
Résumé
Heterogeneous nuclear ribonucleoprotein L (hnRNPL) is a type of RNA binding protein that is mainly located in the nucleus. hnRNPL protein, encoded by the gene located at 19q13.2, is an important member of the hnRNP family. In recent years, studies have shown that hnRNPL is highly expressed in a variety of tumors and plays a vital role in tumor progression. hnRNPL promotes various biological processes of tumor cells, including proliferation, migration and invasion. In this review, we discuss the clinical significance of hnRNPL by reviewing the mechanism of hnRNPL in the tumorigenesis of various cancers.
Identifiants
pubmed: 32376323
pii: S0009-8981(20)30197-2
doi: 10.1016/j.cca.2020.04.040
pii:
doi:
Substances chimiques
HNRNPL protein, human
0
Ribonucleoproteins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
286-294Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no conflict of interests.