Phenytoin - An anti-seizure drug: Overview of its chemistry, pharmacology and toxicology.
Cerebellar atrophy
DRESS syndrome
Pharmacokinetics
Phenytoin
Side effect
Toxicity
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
ISSN: 1873-6351
Titre abrégé: Food Chem Toxicol
Pays: England
ID NLM: 8207483
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
01
01
2020
revised:
16
04
2020
accepted:
24
04
2020
pubmed:
8
5
2020
medline:
30
3
2021
entrez:
8
5
2020
Statut:
ppublish
Résumé
Phenytoin is a long-standing, anti-seizure drug widely used in clinical practice. It has also been evaluated in the context of many other illnesses in addition to its original epilepsy indication. The narrow therapeutic index of phenytoin and its ubiquitous daily use pose a high risk of poisoning. This review article focuses on the chemistry, pharmacokinetics, and toxicology of phenytoin, with a special focus on its mutagenicity, carcinogenicity, and teratogenicity. The side effects on human health associated with phenytoin use are thoroughly described. In particular, DRESS syndrome and cerebellar atrophy are addressed. This review will help in further understanding the benefits phenytoin use in the treatment of epilepsy.
Identifiants
pubmed: 32376339
pii: S0278-6915(20)30281-7
doi: 10.1016/j.fct.2020.111393
pii:
doi:
Substances chimiques
Anticonvulsants
0
Teratogens
0
Phenytoin
6158TKW0C5
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
111393Informations de copyright
Copyright © 2020. Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.