[Expression of kinesin KIF3A in the kidney of mice with unilateral ureteral obstruction].
KIF3A
epithelial-mesenchymal transition
renal tubulointerstitial fibrosis
wnt4/β-catenin signaling pathway
Journal
Nan fang yi ke da xue xue bao = Journal of Southern Medical University
ISSN: 1673-4254
Titre abrégé: Nan Fang Yi Ke Da Xue Xue Bao
Pays: China
ID NLM: 101266132
Informations de publication
Date de publication:
29 Feb 2020
29 Feb 2020
Historique:
entrez:
8
5
2020
pubmed:
8
5
2020
medline:
14
7
2020
Statut:
ppublish
Résumé
To investigate the expression of KIF3A in mice with unilateral ureteral obstruction (UUO) and TGF-β1-induced NRK-52E cells and the role of KIF3A in renal tubular epithelial cell transdifferentiation. Thirty-six C57BL/6J mice were randomly divided into the sham group ( Compared with the sham-operated mice, the mice with UUO showed worsened renal interstitial fibrosis with the increase of obstruction time, indicating successful modeling. The expressions of KIF3A mRNA and protein increased progressively and reached the peaked level at 21 days after UUO. The expression of α-SMA protein was significantly increased while E-cadherin protein expression was significantly reduced after UUO. The transdifferentiated NRK-52E cells showed significantly increased expressions of KIF3A ( KIF3A may participate in the development of renal fibrosis through epithelial-mesenchymal transition mediated by wnt/β-catenin signaling pathway.
Identifiants
pubmed: 32376524
doi: 10.12122/j.issn.1673-4254.2020.02.13
pmc: PMC7086125
doi:
Substances chimiques
Kif3a protein, mouse
0
Transforming Growth Factor beta1
0
Kinesins
EC 3.6.4.4
Types de publication
Journal Article
Langues
chi
Sous-ensembles de citation
IM
Pagination
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