[Expressions of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinases 1 in skeletal muscles of aged rats with sarcopenia].
extracellular matrix
matrix metalloproteinase-1
sarcopenia
tissue inhibitor of metalloproteinases-1
Journal
Nan fang yi ke da xue xue bao = Journal of Southern Medical University
ISSN: 1673-4254
Titre abrégé: Nan Fang Yi Ke Da Xue Xue Bao
Pays: China
ID NLM: 101266132
Informations de publication
Date de publication:
30 Jan 2020
30 Jan 2020
Historique:
entrez:
8
5
2020
pubmed:
8
5
2020
medline:
1
7
2020
Statut:
ppublish
Résumé
To investigate the changes of skeletal muscle mass and strength and the expressions of matrix metalloproteinase-1 (MMP-1), tissue inhibitor of metalloproteinases-1 (TIMP-1) and collagen-1 in the skeletal muscle of aged rats with sarcopenia. With 11 young (6-month-old) SD rats as control group, 18 aged (25-month-old) SD rats were divided into two groups (n=9) according to the relative lean mass determined dual X-ray absorptiometry (DXA), namely aged control group and aged sarcopenia group (the relative lean mass was 2SD higher in aged control than in aged sarcopenia group. The forelimb grip strength of the rats was measured using an electronic grip strength meter. The extracellular matrix (ECM) of the rat's gastrocnemius was observed with HE staining and sirius Red staining, and the protein expressions of collagen-1, MMP-1, and TIMP-1 in the muscular tissues were detected with Western blotting. Compared with the young rats, the aged control rats had significantly lower relative grip strength ( MMP-1/TIMP-1 imbalance in the skeletal muscle during aging affects ECM metabolism and leads to increased collagen fibers, which in turn affects the skeletal muscle mass and function and contribute to the onset of sarcopenia.
Identifiants
pubmed: 32376563
doi: 10.12122/j.issn.1673-4254.2020.01.17
pmc: PMC7040751
doi:
Substances chimiques
TIMP1 protein, rat
0
Tissue Inhibitor of Metalloproteinase-1
0
Matrix Metalloproteinase 13
EC 3.4.24.-
MMP1 protein, rat
EC 3.4.24.7
Matrix Metalloproteinase 1
EC 3.4.24.7
Types de publication
Journal Article
Langues
chi
Sous-ensembles de citation
IM
Pagination
104-109Références
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