Inhibition of SARS-CoV-2 Infection by the Cyclophilin Inhibitor Alisporivir (Debio 025).
Animals
Antiviral Agents
/ pharmacology
Betacoronavirus
/ drug effects
COVID-19
Cell Line
Chlorocebus aethiops
Coronavirus Infections
/ drug therapy
Cyclophilins
/ antagonists & inhibitors
Cyclosporine
/ pharmacology
Humans
Pandemics
Pneumonia, Viral
/ drug therapy
SARS-CoV-2
Vero Cells
Virus Replication
/ drug effects
SARS-CoV-2
alisporivir
antiviral
cyclophilin
Journal
Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061
Informations de publication
Date de publication:
23 06 2020
23 06 2020
Historique:
received:
03
05
2020
accepted:
04
05
2020
pubmed:
8
5
2020
medline:
7
7
2020
entrez:
8
5
2020
Statut:
epublish
Résumé
Cyclophilins play a key role in the life cycle of coronaviruses. Alisporivir (Debio 025) is a nonimmunosuppressive analogue of cyclosporine with potent cyclophilin inhibition properties. Alisporivir reduced SARS-CoV-2 RNA production in a dose-dependent manner in Vero E6 cells, with a 50% effective concentration (EC
Identifiants
pubmed: 32376613
pii: AAC.00876-20
doi: 10.1128/AAC.00876-20
pmc: PMC7318051
pii:
doi:
Substances chimiques
Antiviral Agents
0
Cyclosporine
83HN0GTJ6D
Cyclophilins
EC 5.2.1.-
alisporivir
VBP9099AA6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2020 American Society for Microbiology.
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