CD25-Targeted IL-2 Signals Promote Improved Outcomes of Influenza Infection and Boost Memory CD4 T Cell Formation.
Animals
Antibodies, Monoclonal
/ immunology
CD4-Positive T-Lymphocytes
/ immunology
Cytokines
/ immunology
Female
Immunologic Memory
/ immunology
Inflammation
/ immunology
Influenza A virus
/ immunology
Interleukin-2
/ immunology
Interleukin-2 Receptor alpha Subunit
/ immunology
Lung
/ immunology
Male
Mice
Mice, Inbred BALB C
Orthomyxoviridae Infections
/ immunology
T-Lymphocytes, Regulatory
/ immunology
Up-Regulation
/ immunology
Journal
Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R
Informations de publication
Date de publication:
15 06 2020
15 06 2020
Historique:
received:
25
02
2020
accepted:
16
04
2020
pubmed:
8
5
2020
medline:
13
2
2021
entrez:
8
5
2020
Statut:
ppublish
Résumé
IL-2 is a pleotropic cytokine with potent pro- and anti-inflammatory effects. These divergent impacts can be directed in vivo by forming complexes of IL-2 and anti-IL-2 mAbs (IL-2C) to target IL-2 to distinct subsets of cells based on their expression of subunits of the IL-2R. In this study, we show that treatment of mice with a prototypical anti-inflammatory IL-2C, JES6-1-IL-2C, best known to induce CD25
Identifiants
pubmed: 32376651
pii: jimmunol.2000205
doi: 10.4049/jimmunol.2000205
pmc: PMC7327712
mid: NIHMS1598870
doi:
Substances chimiques
Antibodies, Monoclonal
0
Cytokines
0
Il2ra protein, mouse
0
Interleukin-2
0
Interleukin-2 Receptor alpha Subunit
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3307-3314Subventions
Organisme : NIAID NIH HHS
ID : R21 AI153120
Pays : United States
Organisme : Medical Research Council
ID : MR/P011136/1
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : R21 AI117457
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI109858
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI118820
Pays : United States
Organisme : NICHD NIH HHS
ID : R21 HD093948
Pays : United States
Informations de copyright
Copyright © 2020 by The American Association of Immunologists, Inc.
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