Preclinical validation of a repurposed metal chelator as an early-intervention therapeutic for hemotoxic snakebite.


Journal

Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086

Informations de publication

Date de publication:
06 05 2020
Historique:
received: 06 08 2019
revised: 22 01 2020
accepted: 19 03 2020
entrez: 8 5 2020
pubmed: 8 5 2020
medline: 24 6 2021
Statut: ppublish

Résumé

Snakebite envenoming causes 138,000 deaths annually, and ~400,000 victims are left with permanent disabilities. Envenoming by saw-scaled vipers (Viperidae:

Identifiants

pubmed: 32376771
pii: 12/542/eaay8314
doi: 10.1126/scitranslmed.aay8314
pmc: PMC7116364
mid: EMS103580
pii:
doi:

Substances chimiques

Chelating Agents 0
Viper Venoms 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Medical Research Council
ID : MC_PC_15040
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 200517
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 200517/Z/16/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_18055
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S00016X/1
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

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Auteurs

Laura-Oana Albulescu (LO)

Centre for Snakebite Research and Interventions, Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA Liverpool, UK.

Melissa S Hale (MS)

Centre for Snakebite Research and Interventions, Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA Liverpool, UK.

Stuart Ainsworth (S)

Centre for Snakebite Research and Interventions, Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA Liverpool, UK.

Jaffer Alsolaiss (J)

Centre for Snakebite Research and Interventions, Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA Liverpool, UK.

Edouard Crittenden (E)

Centre for Snakebite Research and Interventions, Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA Liverpool, UK.

Juan J Calvete (JJ)

Laboratorio de Venómica Estructural y Funcional, Instituto de Biomedicina de Valencia, CSIC, Valencia 46010, Spain.

Chloe Evans (C)

Centre for Snakebite Research and Interventions, Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA Liverpool, UK.

Mark C Wilkinson (MC)

Centre for Snakebite Research and Interventions, Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA Liverpool, UK.

Robert A Harrison (RA)

Centre for Snakebite Research and Interventions, Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA Liverpool, UK.
Centre for Drugs and Diagnostics, Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA Liverpool, UK.

Jeroen Kool (J)

Amsterdam Institute for Molecules Medicines and Systems, Division of BioAnalytical Chemistry, Department of Chemistry and Pharmaceutical Sciences, Faculty of Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081HV Amsterdam, Netherlands.

Nicholas R Casewell (NR)

Centre for Snakebite Research and Interventions, Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA Liverpool, UK. nicholas.casewell@lstmed.ac.uk.
Centre for Drugs and Diagnostics, Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA Liverpool, UK.

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