Somatic Tissue Engineering in Mouse Models Reveals an Actionable Role for WNT Pathway Alterations in Prostate Cancer Metastasis.
Journal
Cancer discovery
ISSN: 2159-8290
Titre abrégé: Cancer Discov
Pays: United States
ID NLM: 101561693
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
22
10
2019
revised:
26
03
2020
accepted:
01
05
2020
pubmed:
8
5
2020
medline:
20
11
2021
entrez:
8
5
2020
Statut:
ppublish
Résumé
To study genetic factors influencing the progression and therapeutic responses of advanced prostate cancer, we developed a fast and flexible system that introduces genetic alterations relevant to human disease directly into the prostate glands of mice using tissue electroporation. These electroporation-based genetically engineered mouse models (EPO-GEMM) recapitulate features of traditional germline models and, by modeling genetic factors linked to late-stage human disease, can produce tumors that are metastatic and castration-resistant. A subset of tumors with
Identifiants
pubmed: 32376773
pii: 2159-8290.CD-19-1242
doi: 10.1158/2159-8290.CD-19-1242
pmc: PMC7334089
mid: NIHMS1592352
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1038-1057Subventions
Organisme : NCI NIH HHS
ID : R01 CA193837
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA092629
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA233944
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA155169
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA087497
Pays : United States
Organisme : NCI NIH HHS
ID : U54 CA224079
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA183929
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA160001
Pays : United States
Organisme : NIH HHS
ID : U54 OD020355
Pays : United States
Organisme : NCI NIH HHS
ID : K99 CA241110
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA173481
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Informations de copyright
©2020 American Association for Cancer Research.
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