Dopaminergic Plasticity in the Bilateral Hippocampus Following Threat Reversal in Humans.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
06 05 2020
06 05 2020
Historique:
received:
03
10
2019
accepted:
06
04
2020
entrez:
8
5
2020
pubmed:
8
5
2020
medline:
2
12
2020
Statut:
epublish
Résumé
When a cue no longer predicts a threat, a diminished ability to extinguish or reverse this association is thought to increase risk for stress-related disorders. Despite the clear clinical relevance, the mediating neurochemical mechanisms of threat reversal have received relatively little study. One neurotransmitter implicated in rodent research of changing associations with threat is dopamine. To study whether dopamine is involved in threat reversal in humans, we used high-resolution positron emission tomography (PET) coupled with
Identifiants
pubmed: 32376865
doi: 10.1038/s41598-020-63977-7
pii: 10.1038/s41598-020-63977-7
pmc: PMC7203150
doi:
Substances chimiques
Dopamine
VTD58H1Z2X
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
7627Subventions
Organisme : Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada)
ID : MOP-119509
Pays : International
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