Predictive Factors for Lymph Node Metastasis and the Effect on Survival in Early Gastric Cancer Patients with Radical Gastric Resection.
Early gastric cancer
gastric cancer
lymph node metastasis
Journal
Sisli Etfal Hastanesi tip bulteni
ISSN: 1302-7123
Titre abrégé: Sisli Etfal Hastan Tip Bul
Pays: Turkey
ID NLM: 9424130
Informations de publication
Date de publication:
2019
2019
Historique:
received:
20
08
2019
accepted:
27
08
2019
entrez:
8
5
2020
pubmed:
8
5
2020
medline:
8
5
2020
Statut:
epublish
Résumé
Selected patients with early gastric cancer (GC) are treated endoscopically. Lymph node metastasis (LNM) in the T1 stage may also be detected during surgical resection for early GC. The aim of this study was to determine factors associated with LNM and the effect on survival. A total of 63 patients with tumor invasion stage T1a or T1b who were operated on for early GC between 2010 and 2018 were included in the study. Parameters were investigated retrospectively to identify predictive factors for LNM and overall survival. Significance was defined with a 2-sided p-value of <0.05. Among the 63 patients, 21 (33.3%) had LNM. Lymphovascular invasion (LVI) (p=0.02) and a high-grade tumor (p=0.02) were significantly associated with LNM. The overall survival rate was 73.0%. The number of patients with LNM was greater among the deceased patients compared with the censored group (p=0.03). The median follow-up time of the entire group was 28 months (range: 12-55 months) while it was 23 months (range: 7-39 months) in the deceased group and 33.5 months (15.5-60 months) in the censored group (p=0.06). The mean survival was 62.36 months in patients with LNM and 71.99 months in those without LNM (p=0.09). The cut-off value determined for the neutrophil-to-lymphocyte ratio (NLR) was 2.33 and it was an effective value in survival analysis (p<0.05). Surgical treatment should be considered for early GC patients with high-grade tumors and cases demonstrating LVI. The overall survival was shorter in patients with a high NLR value and LNM.
Identifiants
pubmed: 32377111
doi: 10.14744/SEMB.2019.30643
pii: MBSEH-53-371
pmc: PMC7192292
doi:
Types de publication
Journal Article
Langues
eng
Pagination
371-378Informations de copyright
Copyright: © 2019 by The Medical Bulletin of Sisli Etfal Hospital.
Déclaration de conflit d'intérêts
Conflict of interest: None declared.
Références
J Surg Res. 2014 Sep;191(1):130-3
pubmed: 24768142
Cancer. 1950 Jan;3(1):32-5
pubmed: 15405679
Scand J Gastroenterol. 2015 Mar;50(3):368-75
pubmed: 25582554
Ann Surg Oncol. 2010 Jul;17(7):1721-4
pubmed: 20369299
J Gastrointest Surg. 2016 Mar;20(3):531-8
pubmed: 26385006
Pathol Res Pract. 2016 May;212(5):410-4
pubmed: 26907784
PLoS One. 2015 Dec 10;10(12):e0144774
pubmed: 26658344
Endoscopy. 2018 May;50(5):479-486
pubmed: 29228402
World J Gastroenterol. 2014 May 14;20(18):5389-95
pubmed: 24833868
J Cancer. 2017 Apr 10;8(7):1214-1222
pubmed: 28607596
Ann Surg Oncol. 2010 Dec;17(12):3077-9
pubmed: 20882416
World J Gastroenterol. 2006 Jan 7;12(1):43-7
pubmed: 16440415
BMC Cancer. 2009 May 20;9:155
pubmed: 19457231
World J Gastroenterol. 2018 Jan 7;24(1):87-95
pubmed: 29358885
J Clin Epidemiol. 2003 Jan;56(1):1-9
pubmed: 12589864
Platelets. 2014;25(8):592-4
pubmed: 23537073
Gastric Cancer. 2017 Jan;20(1):1-19
pubmed: 27342689
Oncotarget. 2018 Jan 18;9(10):9262-9272
pubmed: 29507688
Gastrointest Endosc. 2016 May;83(5):896-901
pubmed: 26344882
J Surg Oncol. 2005 Jun 1;90(3):188-93; discussion 193-4
pubmed: 15895442
Endoscopy. 2009 Feb;41(2):118-22
pubmed: 19214889
PLoS One. 2014 Nov 17;9(11):e111906
pubmed: 25401500
PLoS One. 2014 Nov 06;9(11):e112361
pubmed: 25375150
Oncotarget. 2018 Jan 22;9(12):10808-10817
pubmed: 29535844
Gastric Cancer. 2017 Sep;20(5):843-852
pubmed: 28130712
Gastric Cancer. 2017 Mar;20(Suppl 1):45-52
pubmed: 27807641
Surg Endosc. 2019 Oct;33(10):3228-3237
pubmed: 30511310
Curr Med Sci. 2018 Feb;38(1):78-84
pubmed: 30074155
Oncotarget. 2017 Dec 4;8(69):113758-113765
pubmed: 29371944
Gastric Cancer. 2014 Apr;17(2):387-91
pubmed: 23595619
Tumour Biol. 2016 Jan;37(1):709-14
pubmed: 26242270