New Frontiers in Molecular Imaging with Superparamagnetic Iron Oxide Nanoparticles (SPIONs): Efficacy, Toxicity, and Future Applications.
68Ga-radiolabeled bombesin
Iron oxide nanoparticles
Molecular imaging
Review
SPION
Journal
Nuclear medicine and molecular imaging
ISSN: 1869-3474
Titre abrégé: Nucl Med Mol Imaging
Pays: Germany
ID NLM: 101530478
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
04
11
2019
revised:
23
12
2019
accepted:
22
01
2020
entrez:
8
5
2020
pubmed:
8
5
2020
medline:
8
5
2020
Statut:
ppublish
Résumé
Supermagnetic Iron Oxide Nanoparticles (SPIONs) are nanoparticles that have an iron oxide core and a functionalized shell. SPIONs have recently raised much interest in the scientific community, given their exciting potential diagnostic and theragnostic applications. The possibility to modify their surface and the characteristics of their core make SPIONs a specific contrast agent for magnetic resonance imaging but also an intriguing family of tracer for nuclear medicine. An example is 68Ga-radiolabeled bombesin-conjugated to superparamagnetic nanoparticles coated with trimethyl chitosan that is selective for the gastrin-releasing peptide receptors. These receptors are expressed by several human cancer cells such as breast and prostate neoplasia. Since the coating does not interfere with the properties of the molecules bounded to the shell, it has been proposed to link SPIONs with antibodies. SPIONs can be used also to monitor the biodistribution of mesenchymal stromal cells and take place in various applications. The aim of this review of literature is to analyze the diagnostic aspect of SPIONs in magnetic resonance imaging and in nuclear medicine, with a particular focus on sentinel lymph node applications. Moreover, it is taken into account the possible toxicity and the effects on human physiology to determine the SPIONs' safety.
Identifiants
pubmed: 32377258
doi: 10.1007/s13139-020-00635-w
pii: 635
pmc: PMC7198685
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
65-80Informations de copyright
© Korean Society of Nuclear Medicine 2020.
Déclaration de conflit d'intérêts
Conflict of InterestViviana Frantellizzi, Miriam Conte, Mariano Pontico, Arianna Pani, Roberto Pani, and Giuseppe De Vincentis declare that they have no conflict of interest.
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