Upregulation of Phosphatase 1 Nuclear-Targeting Subunit (PNUTS) Is an Independent Predictor of Poor Prognosis in Prostate Cancer.
Journal
Disease markers
ISSN: 1875-8630
Titre abrégé: Dis Markers
Pays: United States
ID NLM: 8604127
Informations de publication
Date de publication:
2020
2020
Historique:
received:
17
01
2020
accepted:
17
01
2020
entrez:
8
5
2020
pubmed:
8
5
2020
medline:
3
2
2021
Statut:
epublish
Résumé
Protein phosphatase 1 nuclear-targeting subunit (PNUTS) is ubiquitously expressed and associates with PTEN and protein phosphatase 1 (PP1) to control its activity. The role of PNUTS overexpression has hardly been studied in cancer. In this study, we used immunohistochemistry to quantitate PNUTS expression on a tissue microarray containing 17,747 clinical prostate cancer specimens. As compared to normal prostate epithelium, PNUTS expression was often higher in cancer. Among 12,235 interpretable tumors, PNUTS staining was negative in 21%, weak in 34%, moderate in 35%, and strong in 10% of cases. High PNUTS expression was associated with higher tumor stage, classical and quantitative Gleason grade, nodal stage, surgical margin, Ki67 labeling index, and early biochemical recurrence (
Identifiants
pubmed: 32377272
doi: 10.1155/2020/7050146
pmc: PMC7196962
doi:
Substances chimiques
Biomarkers, Tumor
0
DNA-Binding Proteins
0
Oncogene Proteins, Fusion
0
PPP1R10 protein, human
0
RNA-Binding Proteins
0
TMPRSS2-ERG fusion protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
7050146Informations de copyright
Copyright © 2020 Andreas Marx et al.
Déclaration de conflit d'intérêts
The authors declare that they have no competing interests.
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