Fernblock® Upregulates NRF2 Antioxidant Pathway and Protects Keratinocytes from PM


Journal

Oxidative medicine and cellular longevity
ISSN: 1942-0994
Titre abrégé: Oxid Med Cell Longev
Pays: United States
ID NLM: 101479826

Informations de publication

Date de publication:
2020
Historique:
received: 04 01 2020
accepted: 07 02 2020
entrez: 8 5 2020
pubmed: 8 5 2020
medline: 5 2 2021
Statut: epublish

Résumé

Humans in modern industrial and postindustrial societies face sustained challenges from environmental pollutants, which can trigger tissue damage from xenotoxic stress through different mechanisms. Thus, the identification and characterization of compounds capable of conferring antioxidant effects and protection against these xenotoxins are warranted. Here, we report that the natural extract of

Identifiants

pubmed: 32377294
doi: 10.1155/2020/2908108
pmc: PMC7181013
doi:

Substances chimiques

Antioxidants 0
NF-E2-Related Factor 2 0
Plant Extracts 0
Protective Agents 0
fernblock 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

2908108

Informations de copyright

Copyright © 2020 Pablo Delgado-Wicke et al.

Déclaration de conflit d'intérêts

S.G. has a consultant role for Cantabria Labs, and A. R.-L. belongs to the Medical Affairs Department at Cantabria Labs, which produced Fernblock®. Y.I. and Y.H. belong to the Rohto Basic Research Development Division, which distributed Fernblock®. The remaining authors declare no conflict of interest.

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Auteurs

Pablo Delgado-Wicke (P)

Department of Biology, Faculty of Sciences, Autónoma University of Madrid (UAM) 28049, Madrid, Spain.

Azahara Rodríguez-Luna (A)

Medical Affairs Department, Cantabria Labs, 28043 Madrid, Spain.

Yoshifumi Ikeyama (Y)

Rohto Basic Research Development Division, Tokyo, Japan.

Yoichi Honma (Y)

Rohto Basic Research Development Division, Tokyo, Japan.

Toshiaki Kume (T)

Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani, Toyama, Japan.

María Gutierrez (M)

Department of Biology, Faculty of Sciences, Autónoma University of Madrid (UAM) 28049, Madrid, Spain.

Silvia Lorrio (S)

Department of Biology, Faculty of Sciences, Autónoma University of Madrid (UAM) 28049, Madrid, Spain.

Ángeles Juarranz (Á)

Department of Biology, Faculty of Sciences, Autónoma University of Madrid (UAM) 28049, Madrid, Spain.
Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain.

Salvador González (S)

Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain.
Department of Medicine and Medical Specialties, Alcalá de Henares University, 28805 Madrid, Spain.

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Classifications MeSH