Carrageenan-Free Diet Shows Improved Glucose Tolerance and Insulin Signaling in Prediabetes: A Randomized, Pilot Clinical Trial.
Journal
Journal of diabetes research
ISSN: 2314-6753
Titre abrégé: J Diabetes Res
Pays: England
ID NLM: 101605237
Informations de publication
Date de publication:
2020
2020
Historique:
received:
20
09
2019
revised:
30
01
2020
accepted:
04
03
2020
entrez:
8
5
2020
pubmed:
8
5
2020
medline:
17
2
2021
Statut:
epublish
Résumé
Carrageenan is well known to cause inflammation and is used in laboratory experiments to study mediators and treatments of inflammation. However, carrageenan is added to hundreds of processed foods to improve texture. Previous work indicated that low concentrations of carrageenan in drinking water caused marked glucose intolerance and insulin resistance in a mouse model. This exploratory, clinical study tested the impact of the no-carrageenan diet in prediabetes. Subjects on no carrageenan had declines in HbA1c and HOMA-IR ( Findings indicate improvement in HbA1c and HOMA-IR in participants on no-carrageenan diets, but not in participants on carrageenan-containing diets. Significant differences between groups suggest that removing carrageenan may improve insulin signaling and glucose tolerance. Larger studies are needed to further consider the impact of carrageenan on development of diabetes.
Identifiants
pubmed: 32377523
doi: 10.1155/2020/8267980
pmc: PMC7191375
doi:
Substances chimiques
Blood Glucose
0
Insulin
0
Carrageenan
9000-07-1
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
8267980Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR002003
Pays : United States
Informations de copyright
Copyright © 2020 Leo Feferman et al.
Déclaration de conflit d'intérêts
The authors have no conflict of interest with regard to this manuscript.
Références
PLoS One. 2016 Apr 14;11(4):e0153463
pubmed: 27078017
Diabetes Care. 2010 Apr;33(4):861-8
pubmed: 20067962
J Biol Chem. 2015 Apr 24;290(17):10764-74
pubmed: 25784556
Oncogene. 2014 Nov 20;33(47):5467-76
pubmed: 24240681
Crit Rev Toxicol. 2014 Mar;44(3):244-69
pubmed: 24467586
Rev Diabet Stud. 2016 Winter;13(4):226-235
pubmed: 28278309
Endocrine. 2014 Sep;47(1):107-16
pubmed: 24744219
Am J Physiol Gastrointest Liver Physiol. 2007 Mar;292(3):G829-38
pubmed: 17095757
Diabetes Care. 2009 Feb;32(2):335-41
pubmed: 18957530
J Diabetes Res. 2019 Apr 15;2019:9582714
pubmed: 31179345
J Nutr Biochem. 2010 Oct;21(10):906-13
pubmed: 19864123
J Biol Chem. 2008 Apr 18;283(16):10550-8
pubmed: 18252714
Pediatr Pulmonol. 2013 Mar;48(3):236-44
pubmed: 22550062
Biochim Biophys Acta. 2012 Aug;1822(8):1300-7
pubmed: 22579587
Diabetes. 2016 Aug;65(8):2224-34
pubmed: 27207509
Biochim Biophys Acta. 2008 Jul-Aug;1780(7-8):973-82
pubmed: 18452717
Am J Clin Nutr. 1990 Feb;51(2):241-7
pubmed: 2305711
Nutr Healthy Aging. 2017 Mar 31;4(2):181-192
pubmed: 28447072
Food Chem Toxicol. 2015 Mar;77:120-31
pubmed: 25592784
J Clin Invest. 2006 Nov;116(11):3015-25
pubmed: 17053832
Nutrients. 2018 Sep 06;10(9):
pubmed: 30200572
Mol Cell Endocrinol. 2014 Jan 25;382(1):66-73
pubmed: 24055274
J Nutr Biochem. 2012 Sep;23(9):1058-63
pubmed: 22079206
JAMA Intern Med. 2017 Dec 1;177(12):1808-1817
pubmed: 29114778
Environ Health Perspect. 2001 Oct;109(10):983-94
pubmed: 11675262
Diabetologia. 2012 Jan;55(1):194-203
pubmed: 22011715
Crit Rev Food Sci Nutr. 2019;59(19):3054-3073
pubmed: 29902080
Diabetes Care. 2011 Jan;34(1):14-9
pubmed: 20929998
Oncotarget. 2017 Oct 27;8(59):100242-100260
pubmed: 29245974
J Nutr. 2017 Jun;147(6):1174-1182
pubmed: 28424256
Am Heart J. 2004 Dec;148(6):1034-40
pubmed: 15632890
Cell. 2016 Nov 3;167(4):973-984.e12
pubmed: 27814523
J Diabetes Res. 2015;2015:513429
pubmed: 25883986
Diabetes. 2019 Aug;68(8):1577-1590
pubmed: 31127058
Diabetes Care. 2004 Jun;27(6):1487-95
pubmed: 15161807
J Clin Endocrinol Metab. 2000 Jul;85(7):2402-10
pubmed: 10902785
Biochimie. 2012 Jun;94(6):1309-16
pubmed: 22410212
J Biol Chem. 2018 Jul 13;293(28):11076-11087
pubmed: 29794138