Differences in plasma metabolites related to Alzheimer's disease,
APOE ε4
Alzheimer's disease
metabolite profile differences in Alzheimer's disease
metabolomics
multi‐ethnic
plasma
Journal
Alzheimer's & dementia (New York, N. Y.)
ISSN: 2352-8737
Titre abrégé: Alzheimers Dement (N Y)
Pays: United States
ID NLM: 101650118
Informations de publication
Date de publication:
2020
2020
Historique:
received:
26
02
2020
accepted:
31
03
2020
entrez:
8
5
2020
pubmed:
8
5
2020
medline:
8
5
2020
Statut:
epublish
Résumé
We investigated metabolites in plasma to capture systemic biochemical changes associated with Alzheimer's disease (AD). Metabolites in plasma were measured in 59 AD cases and 60 healthy participants of African American (AA), Caribbean Hispanic (CH), and non-Hispanic white (NHW) ancestry using untargeted liquid-chromatography-based ultra-high-resolution mass spectrometry. Metabolite differences between AD and healthy, ethnic groups and apolipoprotein E gene ( A total of 5929 annotated metabolites were measured. Partial least squares discriminant analysis (PLS-DA) inferred that AD clustered separately from healthy controls (area under the curve [AUC] = 0.9816); discriminating pathways included glycerophospholipid, sphingolipid, and non-essential amino acid (alanine, aspartate, glutamate) metabolism. Metabolic features in AA clustered differently from CH and NHW (AUC = 0.9275), and differed between Metabolites, specifically lipids, were associated with AD,
Identifiants
pubmed: 32377558
doi: 10.1002/trc2.12025
pii: TRC212025
pmc: PMC7201178
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e12025Subventions
Organisme : NIEHS NIH HHS
ID : U2C ES030163
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG007232
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG054023
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG037212
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES023839
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001873
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG066107
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG008702
Pays : United States
Organisme : NIA NIH HHS
ID : R56 AG063908
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG066462
Pays : United States
Informations de copyright
© 2020 The Authors. Alzheimer's & Dementia: Translational Research & Clinical Interventions published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association.
Déclaration de conflit d'intérêts
The authors have no conflicts of interest to disclose.
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